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Plasma metabolites ...
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Tessier, Anne JulieHarvard School of Public Health, United States
(author)
Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies
- Article/chapterEnglish2024
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2024
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electronicrdacarrier
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LIBRIS-ID:oai:research.chalmers.se:5d4a9421-02e0-4e05-81e6-68a6ecb853db
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https://research.chalmers.se/publication/540294URI
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https://doi.org/10.1016/j.medj.2024.01.010DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings: The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions: This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding: This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.
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Wang, FengleiHarvard School of Public Health, United States
(author)
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Liang, LimingHarvard School of Public Health, United States,Harvard School of Public Health, United States
(author)
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Wittenbecher, Clemens,1981Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)clemensw
(author)
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Haslam, Danielle E.Harvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Eliassen, A. HeatherHarvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Tobias, Deirdre K.Harvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Li, JunHarvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Zeleznik, OanaBrigham and Women's Hospital
(author)
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Ascherio, AlbertoHarvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Sun, QiHarvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Stampfer, Meir J.Harvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Grodstein, FrancineHarvard School of Public Health, United States,Rush University Medical Center
(author)
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Rexrode, KathrynBrigham and Women's Hospital
(author)
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Manson, Jo Ann E.Harvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Balasubramanian, RajiUniversity of Massachusetts
(author)
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Clish, Clary B.Broad Institute
(author)
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Martínez-González, Miguel A.Harvard School of Public Health, United States,Universidad de Navarra,University of Navarra
(author)
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Chavarro, Jorge E.Harvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Hu, Frank B.Harvard School of Public Health, United States,Brigham and Women's Hospital
(author)
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Guasch-Ferré, MartaHarvard School of Public Health, United States,Novo Nordisk Fonden,Novo Nordisk Foundation
(author)
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Harvard School of Public Health, United StatesChalmers tekniska högskola
(creator_code:org_t)
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In:Med5:3, s. 224-238.e52666-63592666-6340
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Wang, Fenglei
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Liang, Liming
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Tobias, Deirdre ...
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Li, Jun
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Grodstein, Franc ...
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Rexrode, Kathryn
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