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- Ebmeyer, StefanGöteborgs universitet,University of Gothenburg (author)
PER extended-spectrum β-lactamases originate from Pararheinheimera spp
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- Elsevier BV,2019
Numbers
- LIBRIS-ID:oai:research.chalmers.se:66d424b2-240a-4a30-bd4e-f0ff2c1a8548
- https://research.chalmers.se/publication/516217URI
- https://doi.org/10.1016/j.ijantimicag.2018.10.019DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- To investigate the origin of PER extended-spectrum β-lactamases, publicly available sequence databases were searched for bla PER-like genes. Three genomes from Pararheinheimera, a genus associated with water and soil environments, were found to carry bla PER-like genes but lacked the ISCR1/ISPa12/ISPa13 insertion sequences commonly associated with bla PER in clinical isolates. Sequence analysis revealed 78–96% nucleotide identity and conserved synteny between the clinical mobile genetic elements (MGEs) encoding bla PER-1 and the bla PER locus in the Pararheinheimera genomes. Notably, bla PER genes were only identified in 3 of 21 Pararheinheimera and Rheinheimera genomes, whereas the genetic environment of bla PER genes as found in clinical MGEs was conserved in all Pararheinheimera and Rheinheimera genomes. These findings indicate that bla PER genes were likely acquired by a branch of the Pararheinheimera genus long before the antibiotic era. Later, bla PER genes were mobilised, likely through the involvement of insertion sequences, from one or several Pararheinheimera species, allowing their dissemination into human pathogens.
Subject headings and genre
- NATURVETENSKAP Biologi Mikrobiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Microbiology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- Antimicrobial resistance
- Extended-spectrum β-lactamase
- ESBL
- PER-1
- Pararheinheimera
Added entries (persons, corporate bodies, meetings, titles ...)
- Kristiansson, Erik,1978Chalmers tekniska högskola,Chalmers University of Technology,Göteborgs universitet,University of Gothenburg(Swepub:cth)erikkr (author)
- Larsson, D. G. Joakim,1969Göteborgs universitet,University of Gothenburg (author)
- Göteborgs universitetChalmers tekniska högskola (creator_code:org_t)
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- In:International Journal of Antimicrobial Agents: Elsevier BV53:2, s. 158-1641872-79130924-8579
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