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Plasma Alkylresorci...
Plasma Alkylresorcinols Reflect Gluten Intake and Distinguish between Gluten-Rich and Gluten-Poor Diets in a Population at Risk of Metabolic Syndrome
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- Vendelbo Lind, Mads, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Madsen, M. L. (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation
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- Rumessen, J. J. (författare)
- Köpenhamns universitet,University of Copenhagen
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- Vestergaard, H. (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation
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- Gabel, R. J. (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation
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- Hansen, T. (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation
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- Lauritzen, L. (författare)
- Köpenhamns universitet,University of Copenhagen
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- Pedersen, O. B. (författare)
- Novo Nordisk Fonden,Novo Nordisk Foundation
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- Kristensen, M. (författare)
- Köpenhamns universitet,University of Copenhagen
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- Ross, Alastair, 1976 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 1541-6100 .- 0022-3166. ; 146:10, s. 1991-1998
- Relaterad länk:
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https://research.cha...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Many patients with celiac disease experience difficulties in adherence to a gluten-free diet. Methods for testing compliance to a gluten-free diet are costly and cumbersome. Thus, a simple biomarker of gluten intake is needed in a clinical setting and will be useful for epidemiologic studies investigating wider effects of gluten intake. Objective: The aim was to evaluate plasma total alkylresorcinol concentrations as a measure of gluten intake. Methods: In this randomized, controlled, crossover intervention study in 52 Danish adults with features of the metabolic syndrome, we compared 8 wk of a gluten-rich and gluten-poor diet separated by a washout period of wk. We measured fasting plasma concentrations of alkylresorcinols to determine if they reflected differences in gluten intake as a secondary outcome of the original study. In addition, we investigated in 118 Danish adults the cross-sectional association between self reported gluten intake and plasma alkylresorcinols in the same and a similar study at baseline. We used mixed-model ANCOVA for examining treatment effects, a classification tree to determine compliance to the gluten-poor diet, and linear regression models for examining baseline correlation between plasma alkylresorcinol concentrations and gluten intake. Results: Plasma total alkylresorcinols decreased more during the gluten-poor period (geometric mean: -124.8 nmol/L; 95% CI: -156.5, -93.0 nmol/L) than in the gluten-rich period (geometric mean: -31.8 nmol/L; 95% CI: -63.1, -0.4 nmol/L) (P
Ämnesord
- NATURVETENSKAP -- Biologi -- Etologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Behavioural Sciences Biology (hsv//eng)
Nyckelord
- whole-grain wheat
- adolescents
- celiac disease
- gluten
- at-risk
- electrochemical
- rye intake
- detection
- adults
- gluten sensitivity
- celiac-disease
- gluten-related disorders
- biomarkers
- coeliac disease
- cereal-grains
- prevalence
- liquid-chromatography
Publikations- och innehållstyp
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Till lärosätets databas
- Av författaren/redakt...
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Vendelbo Lind, M ...
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Madsen, M. L.
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Rumessen, J. J.
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Vestergaard, H.
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Gabel, R. J.
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Hansen, T.
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Lauritzen, L.
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Pedersen, O. B.
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Kristensen, M.
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Ross, Alastair, ...
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Chalmers tekniska högskola