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Gut Microbiota Regu...
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.
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- Sampson, Timothy R (author)
- California Institute of Technology (Caltech)
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- Debelius, Justine W (author)
- University of California
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- Thron, Taren (author)
- California Institute of Technology (Caltech)
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- Janssen, Stefan (author)
- University of California
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- Shastri, Gauri G (author)
- California Institute of Technology (Caltech)
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- Ilhan, Zehra Esra (author)
- Arizona State University
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- Challis, Collin (author)
- California Institute of Technology (Caltech)
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- Schretter, Catherine E (author)
- California Institute of Technology (Caltech)
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- Rocha, Sandra, 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Gradinaru, Viviana (author)
- California Institute of Technology (Caltech)
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- Chesselet, Marie-Francoise (author)
- University of California at Los Angeles (UCLA)
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- Keshavarzian, Ali (author)
- Rush University Medical Center
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- Shannon, Kathleen M (author)
- Rush University Medical Center
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- Krajmalnik-Brown, Rosa (author)
- Arizona State University
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- Wittung Stafshede, Pernilla, 1968 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Knight, Rob (author)
- University of California
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- Mazmanian, Sarkis K (author)
- California Institute of Technology (Caltech)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 167:6, s. 1469-1480.e12
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http://dx.doi.org/10...
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http://www.cell.com/...
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Abstract
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- The intestinal microbiota influence neurodevelopment, modulate behavior, and contribute to neurological disorders. However, a functional link between gut bacteria and neurodegenerative diseases remains unexplored. Synucleinopathies are characterized by aggregation of the protein α-synuclein (αSyn), often resulting in motor dysfunction as exemplified by Parkinson's disease (PD). Using mice that overexpress αSyn, we report herein that gut microbiota are required for motor deficits, microglia activation, and αSyn pathology. Antibiotic treatment ameliorates, while microbial re-colonization promotes, pathophysiology in adult animals, suggesting that postnatal signaling between the gut and the brain modulates disease. Indeed, oral administration of specific microbial metabolites to germ-free mice promotes neuroinflammation and motor symptoms. Remarkably, colonization of αSyn-overexpressing mice with microbiota from PD-affected patients enhances physical impairments compared to microbiota transplants from healthy human donors. These findings reveal that gut bacteria regulate movement disorders in mice and suggest that alterations in the human microbiome represent a risk factor for PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Cell
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- By the author/editor
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Sampson, Timothy ...
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Debelius, Justin ...
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Thron, Taren
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Janssen, Stefan
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Shastri, Gauri G
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Ilhan, Zehra Esr ...
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show more...
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Challis, Collin
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Schretter, Cathe ...
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Rocha, Sandra, 1 ...
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Gradinaru, Vivia ...
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Chesselet, Marie ...
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Keshavarzian, Al ...
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Shannon, Kathlee ...
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Krajmalnik-Brown ...
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Wittung Stafshed ...
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Knight, Rob
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Mazmanian, Sarki ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Cell
- By the university
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Chalmers University of Technology