Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels

• Background: Little is known about the signaling dynamics of AMP-activated protein kinase. Results: We define the dynamics of yeast AMPK signaling under different glucose concentrations. Conclusion: The Snf1-Mig1 signaling system monitors glucose concentration changes and absolute glucose levels to adjust the metabolism to a wide range of conditions. Significance: This description of AMPK signaling dynamics will stimulate studies defining the integration of signaling and metabolism. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

Nuclear Translocation

Yeast Physiology

Glucose Metabolism

AMP-activated Kinase (AMPK)

Dynamic Control

Signal Transduction

AMP-activated Kinase (AMPK); Glucose Metabolism; Nuclear Translocation; Signal Transduction; Yeast Physiology; Dynamic Control

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