Search: WFRF:(Jörnsten Rebecka 1971) >
Integrative discove...
Integrative discovery of treatments for high-risk neuroblastoma
-
- Almstedt, Elin, 1988- (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Elgendy, Ramy (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Hekmati, Neda (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
show more...
-
- Rosén, Emil (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Wärn, Caroline (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Olsen, Thale Kristin (author)
- Karolinska Institute,Karolinska Institutet
-
- Dyberg, Cecilia (author)
- Karolinska Institute,Karolinska Institutet
-
- Doroszko, Milena (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Larsson, Ida (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Sundström, Anders (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Arsenian Henriksson, Marie (author)
- Karolinska Institute,Karolinska Institutet
-
- Påhlman, Sven (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Bexell, Daniel (author)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Vanlandewijck, Michael, 1982- (author)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Department of Medicine, Integrated Cardio-Metabolic Centre Single Cell Facility, Karolinska Institutet, Stockholm, Sweden.
-
- Kogner, Per (author)
- Karolinska Institute,Karolinska Institutet
-
- Jörnsten, Rebecka, 1971 (author)
- Chalmers University of Technology
-
- Krona, Cecilia, 1976- (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
- Nelander, Sven (author)
- Uppsala University,Uppsala universitet,Neuroonkologi
-
show less...
-
(creator_code:org_t)
- 2020-01-03
- 2020
- English.
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://www.nature.c...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with experimental evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumour biobanks, pharmacological databases, and cellular networks to predict how targeted interventions affect mRNA signatures associated with high patient risk or disease processes. We find more than 80 targets to be associated with neuroblastoma risk and differentiation signatures. Selected targets are evaluated in cell lines derived from high-risk patients to demonstrate reversal of risk signatures and malignant phenotypes. Using neuroblastoma xenograft models, we establish CNR2 and MAPK8 as promising candidates for the treatment of high-risk neuroblastoma. We expect that our method, available as a public tool (targettranslator.org), will enhance and expedite the discovery of risk-associated targets for paediatric and adult cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Almstedt, Elin, ...
-
Elgendy, Ramy
-
Hekmati, Neda
-
Rosén, Emil
-
Wärn, Caroline
-
Olsen, Thale Kri ...
-
show more...
-
Dyberg, Cecilia
-
Doroszko, Milena
-
Larsson, Ida
-
Sundström, Ander ...
-
Arsenian Henriks ...
-
Påhlman, Sven
-
Bexell, Daniel
-
Vanlandewijck, M ...
-
Kogner, Per
-
Jörnsten, Rebeck ...
-
Krona, Cecilia, ...
-
Nelander, Sven
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Computer and Inf ...
-
and Bioinformatics
- Articles in the publication
-
Nature Communica ...
- By the university
-
Chalmers University of Technology
-
Uppsala University
-
Karolinska Institutet
-
Lund University