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Seroreactivity agai...
Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage
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- Jons, Daniel (författare)
- Göteborgs universitet,University of Gothenburg,Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden,Univ Gothenburg Sahlgrenska Acad, Sweden; Univ Gothenburg, Sweden
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- Grut, Viktor (författare)
- Umeå universitet,Neurovetenskaper,Umea Univ, Sweden
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- Bergström, Tomas, 1950 (författare)
- Göteborgs universitet,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Department of Infectious Diseases, Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Department of Clinical Microbiology, Sahlgrenska University Hospital, Göteborg, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Biström, Martin, 1982- (författare)
- Umeå universitet,Neurovetenskaper,Umea Univ, Sweden
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- Gunnarsson, Martin, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Vrethem, Magnus (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
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- Brenner, Nicole (författare)
- Deutsches Krebsforschungszentrum (DKFZ),German Cancer Research Center (DKFZ),Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Research Program, German Cancer Research Center, Heidelberg, Germany,German Canc Res Ctr, Germany
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- Butt, Julia (författare)
- Deutsches Krebsforschungszentrum (DKFZ),German Cancer Research Center (DKFZ),Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Research Program, German Cancer Research Center, Heidelberg, Germany,German Canc Res Ctr, Germany
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Nilsson, Staffan, 1956 (författare)
- Göteborgs universitet,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Mathematical Sciences, Chalmers University of Technology, Göteborg, Sweden; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden,Chalmers Univ Technol, Sweden; Univ Gothenburg, Sweden
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- Kockum, Ingrid (författare)
- Karolinska Institutet
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- Olsson, Tomas (författare)
- Karolinska Institutet
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- Waterboer, Tim (författare)
- Deutsches Krebsforschungszentrum (DKFZ),German Cancer Research Center (DKFZ),Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Research Program, German Cancer Research Center, Heidelberg, Germany,German Canc Res Ctr, Germany
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- Sundström, Peter (författare)
- Umeå universitet,Neurovetenskaper,Umea Univ, Sweden
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- Andersen, Oluf, 1941 (författare)
- Göteborgs universitet,University of Gothenburg,Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden,Univ Gothenburg, Sweden
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(creator_code:org_t)
- BMJ Publishing Group Ltd, 2023
- 2023
- Engelska.
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Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ Publishing Group Ltd. - 1468-330X .- 0022-3050.
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Abstract
Ämnesord
Stäng
- Background: Multiple sclerosis (MS) and presymptomatic axonal injury appear to develop only after an Epstein-Barr virus (EBV) infection. This association remains to be confirmed across a broad preclinical time range, for lytic and latent EBV seroreactivity, and for potential cross-reacting antigens. Methods: We performed a case-control study with 669 individual serum samples obtained before clinical MS onset, identified through cross-linkage with the Swedish MS register. We assayed antibodies against EBV nuclear antigen 1 (EBNA1), viral capsid antigen p18, glycoprotein 350 (gp350), the potential cross-reacting protein anoctamin 2 (ANO2) and the level of sNfL, a marker of axonal injury. Results: EBNA1 (latency) seroreactivity increased in the pre-MS group, at 15-20 years before clinical MS onset, followed by gp350 (lytic) seroreactivity (p=0.001-0.009), ANO2 seropositivity appeared shortly after EBNA1-seropositivity in 16.7% of pre-MS cases and 10.0% of controls (p=0.001).With an average lag of almost a decade after EBV, sNfL gradually increased, mainly in the increasing subgroup of seropositive pre-MS cases (p=8.10-5 compared with non-MS controls). Seropositive pre-MS cases reached higher sNfL levels than seronegative pre-MS (p=0.038). In the EBNA1-seropositive pre-MS group, ANO2 seropositive cases had 26% higher sNfL level (p=0.0026). Conclusions: Seroreactivity against latent and lytic EBV antigens, and in a subset ANO2, was detectable on average a decade before the appearance of a gradually increasing axonal injury occurring in the last decade before the onset of clinical MS. These findings strengthen the hypothesis of latent EBV involvement in the pathogenesis of MS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- MULTIPLE SCLEROSIS
- VIROLOGY
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- Av författaren/redakt...
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Jons, Daniel
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Grut, Viktor
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Bergström, Tomas ...
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Zetterberg, Henr ...
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Biström, Martin, ...
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Gunnarsson, Mart ...
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visa fler...
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Vrethem, Magnus
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Brenner, Nicole
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Butt, Julia
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Blennow, Kaj, 19 ...
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Nilsson, Staffan ...
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Kockum, Ingrid
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Olsson, Tomas
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Waterboer, Tim
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Sundström, Peter
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Andersen, Oluf, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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MEDICIN OCH HÄLS ...
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- Artiklar i publikationen
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Journal of Neuro ...
- Av lärosätet
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Chalmers tekniska högskola
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Göteborgs universitet
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Örebro universitet
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Umeå universitet
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Linköpings universitet
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Karolinska Institutet