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Nanostructure-speci...
Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue
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- Georgiadis, Marios (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH),New York University,Stanford University
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- Schroeter, Aileen (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Gao, Zirui (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH),Paul Scherrer Institut
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- Guizar-Sicairos, Manuel (author)
- Paul Scherrer Institut
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- Liebi, Marianne, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Leuze, Christoph (author)
- Stanford University
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- McNab, Jennifer A. (author)
- Stanford University
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- Balolia, Aleezah (author)
- University of Colorado at Denver
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- Veraart, Jelle (author)
- New York University
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- Ades-Aron, Benjamin (author)
- New York University
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- Kim, Sunglyoung (author)
- New York University
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- Shepherd, Timothy (author)
- New York University
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- Lee, Choong H. (author)
- New York University
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- Walczak, Piotr (author)
- Johns Hopkins Medicine,University of Maryland
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- Chodankar, Shirish (author)
- Brookhaven National Laboratory
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- DiGiacomo, Phillip (author)
- Stanford University
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- David, Gergely (author)
- Universität Zürich,University of Zürich
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- Augath, Mark (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Zerbi, Valerio (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Sommer, Stefan (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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Rajkovic, Ivan (author)
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Weiss, Thomas (author)
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- Bunk, Oliver (author)
- Paul Scherrer Institut
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- Yang, Lin (author)
- Brookhaven National Laboratory
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- Zhang, Jiangyang (author)
- New York University
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- Novikov, Dmitry S. (author)
- New York University
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- Zeineh, Michael (author)
- Stanford University
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- Fieremans, Els (author)
- New York University
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- Rudin, Markus (author)
- Universität Zürich,University of Zürich,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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(creator_code:org_t)
- 2021-05-19
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 12:1
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https://research.cha... (primary) (free)
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https://www.nature.c...
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Abstract
Subject headings
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- Myelin insulates neuronal axons and enables fast signal transmission, constituting a key component of brain development, aging and disease. Yet, myelin-specific imaging of macroscopic samples remains a challenge. Here, we exploit myelin’s nanostructural periodicity, and use small-angle X-ray scattering tensor tomography (SAXS-TT) to simultaneously quantify myelin levels, nanostructural integrity and axon orientations in nervous tissue. Proof-of-principle is demonstrated in whole mouse brain, mouse spinal cord and human white and gray matter samples. Outcomes are validated by 2D/3D histology and compared to MRI measurements sensitive to myelin and axon orientations. Specificity to nanostructure is exemplified by concomitantly imaging different myelin types with distinct periodicities. Finally, we illustrate the method’s sensitivity towards myelin-related diseases by quantifying myelin alterations in dysmyelinated mouse brain. This non-destructive, stain-free molecular imaging approach enables quantitative studies of myelination within and across samples during development, aging, disease and treatment, and is applicable to other ordered biomolecules or nanostructures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Georgiadis, Mari ...
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Schroeter, Ailee ...
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Gao, Zirui
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Guizar-Sicairos, ...
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Liebi, Marianne, ...
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Leuze, Christoph
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show more...
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McNab, Jennifer ...
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Balolia, Aleezah
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Veraart, Jelle
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Ades-Aron, Benja ...
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Kim, Sunglyoung
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Shepherd, Timoth ...
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Lee, Choong H.
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Walczak, Piotr
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Chodankar, Shiri ...
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DiGiacomo, Phill ...
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David, Gergely
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Augath, Mark
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Zerbi, Valerio
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Sommer, Stefan
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Rajkovic, Ivan
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Weiss, Thomas
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Bunk, Oliver
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Yang, Lin
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Zhang, Jiangyang
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Novikov, Dmitry ...
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Zeineh, Michael
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Fieremans, Els
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Rudin, Markus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
- Articles in the publication
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Nature Communica ...
- By the university
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Chalmers University of Technology