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Encapsulation of a ...
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Coelho, S. C.Universidade do Porto,University of Porto
(författare)
Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-04-01
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Springer Science and Business Media LLC,2014
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:790e4821-5a0f-4bae-9a92-7587e694615d
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https://research.chalmers.se/publication/216402URI
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https://doi.org/10.1007/s11051-014-2368-4DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Organic-inorganic hybrid nanoparticles are potential effective systems for drug delivery in cancer therapy and diagnosis. Chitosan-gum arabic with entrapped gold nanoparticles were developed as a carrier for an anticancer drug bortezomib. The nanosystem was designed to enhance the proteasome inhibitor activity in pancreatic cell lines, S2-013 and hTERT-HPNE. The hydrodynamic diameter of chitosan-gum arabic-gold nanoparticles loaded with bortezomib is around 330 nm. Laser scanning confocal microscopy images show the uptake of the gold nanoparticle/bortezomib encapsulated in chitosan-gum arabic matrix and the fast internalization of these nano combinations into pancreatic cells. Cytotoxic assays assessed that positively charged nanosystems reduce the cell growth and cell proliferation of S2-013s, but the same effect was not observed in cytotoxic response in hTERT-HPNE cells. The outcomes of this study demonstrate the capacity of chitosan-gum arabic nanocarriers to deliver gold nanoparticles/anticancer drug and to increase the permeation and retention effect in S2-013 cells and minimize drug side effects in HPNE cells. © 2014 Springer Science+Business Media.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rocha, Sandra,1975Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)rochas
(författare)
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Sampaio, P.Instituto de Biologia Molecular e Celular
(författare)
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Pereira, M. C.Universidade do Porto,University of Porto
(författare)
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Coelho, M. A. N.Universidade do Porto,University of Porto
(författare)
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Universidade do PortoChalmers tekniska högskola
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Nanoparticle Research: Springer Science and Business Media LLC16:41388-07641572-896X
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