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Squalene Depletion ...
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Langer, Sarka,1960Chalmers tekniska högskola,Chalmers University of Technology,IVL Svenska Miljöinstitutet AB,IVL Swedish Environmental Research Institute
(author)
Squalene Depletion in Skin Following Human Exposure to Ozone under Controlled Chamber Conditions
- Article/chapterEnglish2024
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Numbers
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LIBRIS-ID:oai:research.chalmers.se:792283cd-a696-4edf-831e-146467ea128a
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https://doi.org/10.1021/acs.est.3c09394DOI
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https://research.chalmers.se/publication/540718URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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A major component of human skin oil is squalene, a highly unsaturated hydrocarbon that protects the skin from atmospheric oxidants. Skin oil, and thus squalene, is continuously replenished on the skin surface. Squalene is also quickly consumed through reactions with ozone and other oxidants. This study examined the extent of squalene depletion in the skin oils of the forearm of human volunteers after exposure to ozone in a climate chamber. Temperature, relative humidity (RH), skin coverage by clothing, and participants’ age were varied in a controlled manner. Concentrations of squalene were determined in skin wipe samples collected before and after ozone exposure. Exposures to ozone resulted in statistically significant decreases in post-exposure squalene concentrations compared to pre-exposure squalene concentrations in the skin wipes when squalene concentrations were normalized by concentrations of co-occurring cholesterol but not by co-occurring pyroglutamic acid (PGA). The rate of squalene loss due to ozonolysis was lower than its replenishment on the skin surface. Within the ranges examined, temperature and RH did not significantly affect the difference between normalized squalene levels in post-samples versus pre-samples. Although not statistically significant, skin coverage and age of the volunteers (three young adults, three seniors, and three teenagers) did appear to impact squalene depletion on the skin surfaces.
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Weschler, Charles J.Danmarks Tekniske Universitet,Technical University of Denmark,Rutgers University
(author)
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Beko, G.Danmarks Tekniske Universitet,Technical University of Denmark
(author)
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Morrison, Glenn
(author)
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Sjöblom, AnnIVL Svenska Miljöinstitutet AB,IVL Swedish Environmental Research Institute
(author)
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Giovanoulis, GeorgiosIVL Svenska Miljöinstitutet AB,IVL Swedish Environmental Research Institute
(author)
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Wargocki, PawelDanmarks Tekniske Universitet,Technical University of Denmark
(author)
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Wang, NijingMax Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
(author)
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Zannoni, NoraMax Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
(author)
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Yang, ShenEcole Polytechnique Federale de Lausanne (EPFL),Swiss Federal Institute of Technology in Lausanne (EPFL)
(author)
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Williams, JonathanMax Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG)
(author)
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Chalmers tekniska högskolaIVL Svenska Miljöinstitutet AB
(creator_code:org_t)
Related titles
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In:Environmental Science & Technology58:15, s. 6693-67030013-936X1520-5851
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Langer, Sarka, 1 ...
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Weschler, Charle ...
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Beko, G.
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Morrison, Glenn
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Sjöblom, Ann
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Giovanoulis, Geo ...
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Wargocki, Pawel
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Wang, Nijing
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Zannoni, Nora
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Yang, Shen
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Williams, Jonath ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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Environmental Sc ...
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Chalmers University of Technology