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Search: WFRF:(Edqvist Per Henrik D) > (2015-2019) > A pathology atlas o...

A pathology atlas of the human cancer transcriptome

Uhlén, Mathias (author)
KTH,Stockholm University,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Center for Biosustainability, Danish Technical University, Copenhagen, Denmark.,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.;Danish Tech Univ, Ctr Biosustainabil, Copenhagen, Denmark.;Royal Inst Technol, AlbaNova Univ Ctr, KTH, Sch Biotechnol, Stockholm, Sweden.
Zhang, C. (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Lee, SangWook (author)
Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
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Sjöstedt, Evelina (author)
Uppsala universitet,KTH,Uppsala University,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden.,Klinisk och experimentell patologi,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Fagerberg, Linn (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Bidkhori, Gholamreza (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Benfeitas, Rui (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Arif, Muhammad (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Liu, Zhengtao (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Edfors, Fredrik (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Sanli, Kemal (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
von Feilitzen, Kalle (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Oksvold, Per (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Lundberg, Emma (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Hober, Sophia, 1965- (author)
KTH,Stockholm University,Skolan för bioteknologi (BIO),Royal Inst Technol, AlbaNova Univ Ctr, KTH, Sch Biotechnol, Stockholm, Sweden.
Nilsson, Peter (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Schwenk, Jochen M. (author)
KTH,KTH Royal Institute of Technology,Uppsala University,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Schwenk, J. M. (author)
Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
Brunnström, Hans (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Div Pathol, Lund, Sweden.
Glimelius, Bengt (author)
Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi
Sjöblom, Tobias (author)
Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi
Edqvist, Per-Henrik D (author)
Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Klinisk och experimentell patologi,Fredrik Pontén
Djureinovic, D. (author)
Uppsala University
Micke, Patrick (author)
Uppsala universitet,Uppsala University,Klinisk och experimentell patologi,Patrick Micke
Lindskog, Cecilia (author)
Uppsala universitet,Uppsala University,Klinisk och experimentell patologi
Mardinoglu, Adil, 1982 (author)
KTH,Stockholm University,KTH Royal Institute of Technology,Chalmers University of Technology,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.;Royal Inst Technol, AlbaNova Univ Ctr, KTH, Sch Biotechnol, Stockholm, Sweden.;Chalmers, Dept Biol & Biol Engn, SE-41296 Gothenburg, Sweden.
Ponten, Fredrik (author)
Uppsala universitet,Uppsala University,Klinisk och experimentell patologi,Fredrik Pontén
Lee, Sunjae (author)
KTH,KTH Royal Institute of Technology,Science for Life Laboratory, SciLifeLab,KTH, Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
Mattsson, Johanna Sofia Margareta, 1985- (author)
Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2017
2017
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 357:6352, s. 660-
Related links:
http://dx.doi.org/10...
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https://doi.org/10.1...
https://doi.org/10.1...
https://research.cha...
https://lup.lub.lu.s...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Keyword

Cell Lung-Cancer
Expression
Metabolism
RNA
Breast-Cancer
Carcinoma
Hallmarks
Patologi

Publication and Content Type

art (subject category)
ref (subject category)

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