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In vivo study of an...
In vivo study of an instantly formed lipid-water cubic phase formulation for efficient topical delivery of aminolevulinic acid and methyl-aminolevulinate
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- Evenbratt, Hanne, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Jonsson, Charlotte A, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Faergemann, Jan, 1948 (author)
- Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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- Engström, Sven, 1951 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Ericson, Marica B, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för fysik (GU),Department of Chemistry and Molecular Biology,Department of Physics (GU)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 452:1-2, s. 270-275
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- We demonstrate a rapidly formed cubic liquid crystalline phase, i.e. typically 1 g cubic phase in less than 1 min confirmed by X-ray diffraction, consisting of an ether lipid, 1-glyceryl monooleyl ether (GME), an aprotic solvent (propylene glycol or pentane-1,5-diol) and water. The efficacy of the cubic formulation was tested in vivo by administrating formulations containing 3% (w/w) of the HCl salts of delta-aminolevulinic acid (ALA) or methylaminolevulinate (MAL) to hairless mice. The endogenous formation of protoporphyrin IX (PpIX) was monitored spectrophotometrically as a marker for cellular uptake of active compound. As reference, a commercial product containing 16% (w/w) MAL in an oil-in-water emulsion (Metvix (R)), and a cubic phase based on an ester lipid (glyceryl monooleate, GMO), previously shown to facilitate topical delivery of both ALA and MAL, were applied. It was found that in general the cubic phases gave rise to higher fluorescence levels than the mice exposed to the commercial product. The instantly formed cubic formulations based on GME demonstrated the same efficiency as the GMO based formulations. The results imply that instantly formed cubic formulations opens up new opportunities, particularly for transdermal drug delivery of substances subject to stability problems in, e. g. aqueous environments.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Keyword
- Aminolevulinic acid
- Glyceryl monooleate
- Methylaminolevulinate
- Instantly formed cubic phase
- Topical delivery
- Glyceryl monooleyl ether
- Instantly formed cubic phase; Topical delivery;Glyceryl monooleyl ether
- Glyceryl monooleate
- Aminolevulinic acid
- Methylaminolevulinate
Publication and Content Type
- art (subject category)
- ref (subject category)
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