Tailor-made conductive inks from cellulose nanofibrils for 3D printing of neural guidelines

Kuzmenko, Volodymyr,1987Chalmers tekniska högskola,Chalmers University of Technology (author)

Neural tissue engineering (TE), an innovative biomedical method of brain study, is very dependent on scaffolds that support cell development into a functional tissue. Recently, 3D patterned scaffolds for neural TE have shown significant positive effects on cells by a more realistic mimicking of actual neural tissue. In this work, we present a conductive nanocellulose-based ink for 3D printing of neural TE scaffolds. It is demonstrated that by using cellulose nanofibrils and carbon nanotubes as ink constituents, it is possible to print guidelines with a diameter below 1 mm and electrical conductivity of 3.8 × 10 −1 S cm −1 . The cell culture studies reveal that neural cells prefer to attach, proliferate, and differentiate on the 3D printed conductive guidelines. To our knowledge, this is the first research effort devoted to using cost-effective cellulosic 3D printed structures in neural TE, and we suppose that much more will arise in the near future.

Karabulut, Erdem,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)erdemk (author)
Pernevik, Elin,1989Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)pernevik (author)
Sanz-Velasco, Anke,1971Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)ankesanz (author)
Gatenholm, Paul,1956Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatenh (author)
Chalmers tekniska högskola (creator_code:org_t)

By the author/editor: Kuzmenko, Volody ...; Karabulut, Erdem ...; Pernevik, Elin, ...; Sanz-Velasco, An ...; Gatenholm, Paul, ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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