Sealing of Submicrometer Wells by a Shear-Driven Lipid Bilayer

Jönsson, Peter,1981Chalmers tekniska högskola,Chalmers University of Technology,Department of Applied Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden (författare)

Funding Agencies|Swedish Research Council for Engineering Sciences [2005-3140]; Swedish Strategic Research Foundation; Royal Physiographic Society in Lund
A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.

Jonsson, Magnus,1981Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)magjons (författare)
Höök, Fredrik,1966Chalmers tekniska högskola,Chalmers University of Technology,Department of Applied Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden(Swepub:cth)fredrikh (författare)
Chalmers tekniska högskolaDepartment of Applied Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden (creator_code:org_t)

Ingår i:Nano Letters: American Chemical Society (ACS)10:5, s. 1900-19061530-69921530-6984

Av författaren/redakt...: Jönsson, Peter, ...; Jonsson, Magnus, ...; Höök, Fredrik, 1 ...

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