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  • Schüz, JInternational Agency for Research on Cancer (IARC) (författare)

Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-03-15
  • Wiley,2016

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:889796af-8985-4cc0-8a26-044bf3e2e332
  • https://doi.org/10.1002/bem.21963DOI
  • https://research.chalmers.se/publication/235605URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:vet swepub-contenttype

Anmärkningar

  • Exposure to extremely low-frequency magnetic fields (ELF-MF) was evaluated in an International Agency for Research on Cancer (IARC) Monographs as possibly carcinogenic to humans in 2001, based on increased childhood leukemia risk observed in epidemiological studies. We conducted a hazard assessment using available scientific evidence published before March 2015, with inclusion of new research findings from the Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment (ARIMMORA) project. The IARC Monograph evaluation scheme was applied to hazard identification. In ARIMMORA for the first time, a transgenic mouse model was used to mimic the most common childhood leukemia: new pathogenic mechanisms were indicated, but more data are needed to draw definitive conclusions. Although experiments in different animal strains showed exposure-related decreases of CD8+ T-cells, a role in carcinogenesis must be further established. No direct damage of DNA by exposure was observed. Overall in the literature, there is limited evidence of carcinogenicity in humans and inadequate evidence of carcinogenicity in experimental animals, with only weak supporting evidence from mechanistic studies. New exposure data from ARIMMORA confirmed that if the association is nevertheless causal, up to 2% of childhood leukemias in Europe, as previously estimated, may be attributable to ELF-MF. In summary, ARIMMORA concludes that the relationship between ELF-MF and childhood leukemia remains consistent with possible carcinogenicity in humans. While this scientific uncertainty is dissatisfactory for science and public health, new mechanistic insight from ARIMMORA experiments points to future research that could provide a step-change in future assessments. Bioelectromagnetics. 37:183-189, 2016.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Dasenbrock, C.Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM (författare)
  • Ravazzani, P.Consiglo Nazionale Delle Richerche (författare)
  • Röösli, MSwiss Tropical and Public Health Institute (Swiss TPH) (författare)
  • Schar, P.Universität Basel,University of Basel (författare)
  • Bounds, P. L.Foundation for Research on Information Technologies in Society (ITIS) (författare)
  • Erdmann, F.International Agency for Research on Cancer (IARC) (författare)
  • Borkhardt, A.Heinrich Heine Universität Düsseldorf,Heinrich Heine University Düsseldorf (författare)
  • Cobaleda, C.CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM) (författare)
  • Fedrowitz, M. (författare)
  • Hamnerius, Yngve,1950Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)elfyngve (författare)
  • Sanchez-Garcia, I. (författare)
  • Seger, R.Weizmann Institute of Science (författare)
  • Schmiegelow, K.Copenhagen University Hospital (författare)
  • Ziegelberger, G.Bundesamt für Strahlenschutz (BfS) (författare)
  • Capstick, M.Foundation for Research on Information Technologies in Society (ITIS) (författare)
  • Manser, M.Universität Basel,University of Basel (författare)
  • Muller, M.Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM (författare)
  • Schmid, C. D.Swiss Tropical and Public Health Institute (Swiss TPH) (författare)
  • Schurmann, D.Universität Basel,University of Basel (författare)
  • Struchen, B.Swiss Tropical and Public Health Institute (Swiss TPH) (författare)
  • Kuster, N.Foundation for Research on Information Technologies in Society (ITIS) (författare)
  • International Agency for Research on Cancer (IARC)Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Bioelectromagnetics: Wiley37:3, s. 183-1891521-186X0197-8462

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