SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Sorokin A.)
 

Search: WFRF:(Sorokin A.) > A community-driven ...

  • Thiele, I.Háskóli Íslands,University of Iceland (author)

A community-driven global reconstruction of human metabolism

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-03-03
  • Springer Science and Business Media LLC,2013

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:8e97b498-ec03-4246-b852-244fb22d6635
  • https://doi.org/10.1038/nbt.2488DOI
  • https://research.chalmers.se/publication/178589URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including similar to 2x more reactions and similar to 1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Swainston, N.University of Manchester (author)
  • Fleming, R. M. T.Háskóli Íslands,University of Iceland (author)
  • Hoppe, A.Charité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Sahoo, S.Háskóli Íslands,University of Iceland (author)
  • Aurich, M. K.Háskóli Íslands,University of Iceland (author)
  • Haraldsdottir, H.Háskóli Íslands,University of Iceland (author)
  • Mo, M. L.University of California (author)
  • Rolfsson, O.Háskóli Íslands,University of Iceland (author)
  • Stobbe, M. D.Netherlands Bioinformatics Centre - NBIC,Universiteit Van Amsterdam,University of Amsterdam (author)
  • Thorleifsson, S. G.Háskóli Íslands,University of Iceland (author)
  • Ågren, Rasmus,1982Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)arasmus (author)
  • Bolling, C.Charité Universitätsmedizin Berlin,Charité University Medicine Berlin (author)
  • Velasco, Sergio,1980Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)velasco (author)
  • Chavali, A. K.University of Virginia (author)
  • Dobson, P.University of Sheffield (author)
  • Dunn, W. B.Christie Hospital NHS Foundation Trust,University of Manchester (author)
  • Endler, L.Universität Wien,University of Vienna (author)
  • Hala, D.University of North Texas (author)
  • Hucka, M.California Institute of Technology (Caltech) (author)
  • Hull, D.University of Manchester (author)
  • Jameson, D.University of Manchester (author)
  • Jamshidi, N.University of California (author)
  • Jonsson, J. J.Háskóli Íslands,University of Iceland (author)
  • Juty, N.European Bioinformatics Institute (author)
  • Keating, S.European Bioinformatics Institute (author)
  • Nookaew, Intawat,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)intawat (author)
  • Le Novere, N.European Bioinformatics Institute,Babraham Institute (author)
  • Malys, N.University of Manchester,The University of Warwick (author)
  • Mazein, A.University of Edinburgh (author)
  • Papin, J. A.University of Virginia (author)
  • Price, N. D.Institute for Systems Biology (author)
  • Selkov, E. (author)
  • Sigurdsson, M. I.Háskóli Íslands,University of Iceland (author)
  • Simeonidis, E.Université du Luxembourg,University of Luxembourg,Institute for Systems Biology (author)
  • Sonnenschein, N. (author)
  • Smallbone, K.University of Manchester (author)
  • Sorokin, A.Russian Academy of Sciences,University of Edinburgh (author)
  • van Beek, JhgmVrije Universiteit Amsterdam (VU) (author)
  • Weichart, D.University of Manchester (author)
  • Goryanin, I.Okinawa Institute of Science and Technology Graduate University,University of Edinburgh (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Westerhoff, H.V.University of Manchester,Vrije Universiteit Amsterdam (VU),Swammerdam Institute for Life Sciences (author)
  • Kell, D. B.University of Manchester (author)
  • Mendes, P.University of Manchester,Virginia Polytechnic Institute and State University (Virginia Tech) (author)
  • Palsson, B. O.Háskóli Íslands,University of Iceland,University of California (author)
  • Háskóli ÍslandsUniversity of Manchester (creator_code:org_t)

Related titles

  • In:Nature Biotechnology: Springer Science and Business Media LLC31:5, s. 419-+1087-01561546-1696

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view