Search: WFRF:(Lutz Bueno Viviane) >
3D nanoscale analys...
3D nanoscale analysis of bone healing around degrading Mg implants evaluated by X-ray scattering tensor tomography
-
- Liebi, Marianne, 1984 (author)
- Eidgenössische Materialprüfungs- und Forschungsanstalt (Empa),Swiss Federal Laboratories for Materials Science and Technology (Empa),Chalmers tekniska högskola,Chalmers University of Technology,Paul Scherrer Institut
-
- Lutz-Bueno, Viviane (author)
- Paul Scherrer Institut
-
- Guizar-Sicairos, Manuel (author)
- Paul Scherrer Institut
-
show more...
-
- Schönbauer, Bernd M. (author)
- Universität für Bodenkultur,University of Natural Resources and Life Sciences
-
- Eichler, Johannes (author)
- Medizinische Universität Graz,Medical University of Graz
-
- Martinelli, Elisabeth (author)
- Medizinische Universität Graz,Medical University of Graz
-
- Löffler, Jörg F. (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
-
- Weinberg, Annelie (author)
- Medizinische Universität Graz,Medical University of Graz
-
- Lichtenegger, Helga (author)
- Universität für Bodenkultur,University of Natural Resources and Life Sciences
-
- Grünewald, Tilman A. (author)
- European Synchrotron Radiation Facility (ESRF)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
-
In: Acta Biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 134, s. 804-817
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://doi.org/10.1...
-
https://doi.org/10.1...
-
https://research.cha...
-
show less...
Abstract
Subject headings
Close
- The nanostructural adaptation of bone is crucial for its biocompatibility with orthopedic implants. The bone nanostructure also determines its mechanical properties and performance. However, the bone's temporal and spatial nanoadaptation around degrading implants remains largely unknown. Here, we present insights into this important bone adaptation by applying scanning electron microscopy, elemental analysis, and small-angle X-ray scattering tensor tomography (SASTT). We extend the novel SASTT reconstruction method and provide a 3D scattering reciprocal space map per voxel of the sample's volume. From this reconstruction, parameters such as the thickness of the bone mineral particles are quantified, which provide additional information on nanostructural adaptation of bone during healing. We selected a rat femoral bone and a degrading ZX10 magnesium implant as model system, and investigated it over the course of 18 months, using a sham as control. We observe that the bone's nanostructural adaptation starts with an initially fast interfacial bone growth close to the implant, which spreads by a re-orientation of the nanostructure in the bone volume around the implant, and is consolidated in the later degradation stages. These observations reveal the complex bulk bone-implant interactions and enable future research on the related biomechanical bone responses. Statement of significance: Traumatic bone injuries are among the most frequent causes of surgical treatment, and often require the placement of an implant. The ideal implant supports and induces bone formation, while being mechanically and chemically adapted to the bone structure, ensuring a gradual load transfer. While magnesium implants fulfill these requirements, the nanostructural changes during bone healing and implant degradation remain not completely elucidated. Here, we unveil these processes in rat femoral bones with ZX10 magnesium implants and show different stages of bone healing in such a model system.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- Tomography
- X-ray scattering
- Biomineralization
- Degradable magnesium implants
- Implant degradation
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Liebi, Marianne, ...
-
Lutz-Bueno, Vivi ...
-
Guizar-Sicairos, ...
-
Schönbauer, Bern ...
-
Eichler, Johanne ...
-
Martinelli, Elis ...
-
show more...
-
Löffler, Jörg F.
-
Weinberg, Anneli ...
-
Lichtenegger, He ...
-
Grünewald, Tilma ...
-
show less...
- About the subject
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Industrial Biote ...
-
and Bio Materials
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Biomaterials Sci ...
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Medical Engineer ...
-
and Medical Material ...
- Articles in the publication
-
Acta Biomaterial ...
- By the university
-
Chalmers University of Technology