Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

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Molinaro, AntonioGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine (author)

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Article/chapterEnglish2020

Publisher, publication year, extent ...

2020-11-18
Springer Science and Business Media LLC,2020
electronicrdacarrier

Numbers

LIBRIS-ID:oai:research.chalmers.se:8f6caa0c-7436-42de-b2ae-9b6bcc19e505
https://research.chalmers.se/publication/520582URI
https://doi.org/10.1038/s41467-020-19589-wDOI
https://gup.ub.gu.se/publication/300292URI

Supplementary language notes

Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
homeostasis model assessment
intestinal microbiota
insulin
sensitivity
accurate method
gut microbiome
glucose
individuals
risk
metagenome
physiology
Science & Technology - Other Topics

Added entries (persons, corporate bodies, meetings, titles ...)

Bel Lassen, Pierre (author)
Henricsson, Marcus,1975Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xstahm (author)
Wu, HaoGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory(Swepub:gu)xwuhaq (author)
Adriouch, Solia (author)
Belda, Eugeni (author)
Chakaroun, RimaUniversität Leipzig,Leipzig University (author)
Nielsen, TrineKöpenhamns universitet,University of Copenhagen (author)
Bergh, Per-OlofGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory(Swepub:gu)xbpero (author)
Rouault, Christine (author)
André, Sébastien (author)
Marquet, Florian (author)
Andreelli, Fabrizio (author)
Salem, Joe-ElieAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Assmann, Karen (author)
Bastard, Jean-PhillippeAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Forslund, Sofia K.Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine (author)
Le Chatelier, EmmanuelleUniversité Paris-Saclay,University Paris-Saclay (author)
Falony, GwenKatholieke Universiteit Leuven (author)
Pons, NicolasUniversité Paris-Saclay,University Paris-Saclay (author)
Prifti, EdiAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Quinquis, BenoitUniversité Paris-Saclay,University Paris-Saclay (author)
Roume, HugoUniversité Paris-Saclay,University Paris-Saclay (author)
Vieira-Silva, SaraKatholieke Universiteit Leuven (author)
Hansen, Tue H.Köpenhamns universitet,University of Copenhagen (author)
Pedersen, Helle K.Köpenhamns universitet,University of Copenhagen (author)
Lewinter, ChristianKöpenhamns universitet,University of Copenhagen (author)
Søndertoft, Nadja B.Köpenhamns universitet,University of Copenhagen (author)
Alves, RenatoEuropean Molecular Biology Laboratory (author)
Amouyal, Chloe (author)
Galijatovic, Ehm Astrid AnderssonKöpenhamns universitet,University of Copenhagen (author)
Barthelemy, OlivierAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Batisse, Jean-PaulAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Berland, MagalieUniversité Paris-Saclay,University Paris-Saclay (author)
Bittar, RandaAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Blottière, HervéUniversité Paris-Saclay,University Paris-Saclay (author)
Bosquet, FredericAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Boubrit, RachidAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Bourron, OlivierAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Camus, MickaelUniversité Paris-Saclay,University Paris-Saclay (author)
Cassuto, DominiqueAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Chilloux, J.Imperial College of Science, Technology and Medicine (author)
Ciangura, CecileAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Coelho, Luis P.European Molecular Biology Laboratory (author)
Collet, Jean-PhilippeAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Dao, Maria-Carlota (author)
Djebbar, MoradAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Doré, AngéliqueUniversité Paris-Saclay,University Paris-Saclay (author)
Engelbrechtsen, Line (author)
Fellahi, SorayaAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Fezeu, Leopold (author)
Fromentin, SebastienUniversité Paris-Saclay,University Paris-Saclay (author)
Giral, PhilippeAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Gøtze, Jens P.Köpenhamns universitet,University of Copenhagen (author)
Hartemann, AgnesAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Holst, Jens JuulKöpenhamns universitet,University of Copenhagen (author)
Hercberg, Serge (author)
Helft, GerardAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Hornbak, MaleneKöpenhamns universitet,University of Copenhagen (author)
Hulot, Jean-Sébastien (author)
Isnard, RichardAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Jaqueminet, SophieUniversité Paris-Saclay,University Paris-Saclay (author)
Jørgensen, Niklas RyeKöpenhamns universitet,University of Copenhagen (author)
Julienne, HannaUniversité Paris-Saclay,University Paris-Saclay (author)
Justesen, JohanneKöpenhamns universitet,University of Copenhagen (author)
Kammer, JudithUniversität Leipzig,Leipzig University (author)
Krarup, NikolajKöpenhamns universitet,University of Copenhagen (author)
Kerneis, MathieuAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Khemis, JeanAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Kristensen, Nadja BuusKöpenhamns universitet,University of Copenhagen (author)
Kuhn, MichaelEuropean Molecular Biology Laboratory (author)
Lejard, VéroniqueUniversité Paris-Saclay,University Paris-Saclay (author)
Levenez, FlorenceUniversité Paris-Saclay,University Paris-Saclay (author)
Lucas-Martini, LeaAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Massey, RobinUniversité Paris-Saclay,University Paris-Saclay (author)
Maziers, NicolasUniversité Paris-Saclay,University Paris-Saclay (author)
Medina-Stamminger, JonathanAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Montalescot, GillesAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Moutel, SandrineAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Le Pavin, Laetitia PaseroUniversité Paris-Saclay,University Paris-Saclay (author)
Poitou, Christine (author)
Pousset, FrancoiseAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Pouzoulet, LaurenceAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Schmidt, SebastianEuropean Molecular Biology Laboratory (author)
Moitinho-Silva, LucasEuropean Molecular Biology Laboratory (author)
Silvain, JohanneAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Sokolovska, Nataliya (author)
Touch, Sothea (author)
Svendstrup, MathildeKöpenhamns universitet,University of Copenhagen (author)
Swartz, Timothy (author)
Vanduyvenboden, ThierryUniversité Paris-Saclay,University Paris-Saclay (author)
Vatier, CamilleAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Walther, StefanieUniversität Leipzig,Leipzig University (author)
Køber, LarsKöpenhamns universitet,University of Copenhagen (author)
Vestergaard, H.Köpenhamns universitet,University of Copenhagen (author)
Hansen, TorbenKöpenhamns universitet,University of Copenhagen (author)
Zucker, Jean-DanielUMMISCO (author)
Galan, Pilar (author)
Dumas, Marc-EmmanuelImperial College of Science, Technology and Medicine (author)
Raes, JeroenUniversité Paris-Saclay,University Paris-Saclay (author)
Oppert, Jean-MichelAssistance publique – Hôpitaux de Paris (AP-HP) (author)
Letunic, IvicaBiobyte Solutions GmbH (author)
Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
Bork, PeerEuropean Molecular Biology Laboratory (author)
Ehrlich, Stanislav DuskoUniversité Paris-Saclay,University Paris-Saclay (author)
Stumvoll, M.Universität Leipzig,Leipzig University (author)
Pedersen, O. B.Köpenhamns universitet,University of Copenhagen (author)
Aron-Wisneswky, Judith (author)
Clement, K. (author)
Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbafre (author)
Bel Lassen, Py (author)
Sonderskov, N. B. (author)
Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

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In:Nature Communications: Springer Science and Business Media LLC11:12041-17232041-1723

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By the author/editor: Molinaro, Antoni ...; Bel Lassen, Pier ...; Henricsson, Marc ...; Wu, Hao; Adriouch, Solia; Belda, Eugeni; show more...; Chakaroun, Rima; Nielsen, Trine; Bergh, Per-Olof; Rouault, Christi ...; André, Sébastien; Marquet, Florian; Andreelli, Fabri ...; Salem, Joe-Elie; Assmann, Karen; Bastard, Jean-Ph ...; Forslund, Sofia ...; Le Chatelier, Em ...; Falony, Gwen; Pons, Nicolas; Prifti, Edi; Quinquis, Benoit; Roume, Hugo; Vieira-Silva, Sa ...; Hansen, Tue H.; Pedersen, Helle ...; Lewinter, Christ ...; Søndertoft, Nadj ...; Alves, Renato; Amouyal, Chloe; Galijatovic, Ehm ...; Barthelemy, Oliv ...; Batisse, Jean-Pa ...; Berland, Magalie; Bittar, Randa; Blottière, Hervé; Bosquet, Frederi ...; Boubrit, Rachid; Bourron, Olivier; Camus, Mickael; Cassuto, Dominiq ...; Chilloux, J.; Ciangura, Cecile; Coelho, Luis P.; Collet, Jean-Phi ...; Dao, Maria-Carlo ...; Djebbar, Morad; Doré, Angélique; Engelbrechtsen, ...; Fellahi, Soraya; Fezeu, Leopold; Fromentin, Sebas ...; Giral, Philippe; Gøtze, Jens P.; Hartemann, Agnes; Holst, Jens Juul; Hercberg, Serge; Helft, Gerard; Hornbak, Malene; Hulot, Jean-Séba ...; Isnard, Richard; Jaqueminet, Soph ...; Jørgensen, Nikla ...; Julienne, Hanna; Justesen, Johann ...; Kammer, Judith; Krarup, Nikolaj; Kerneis, Mathieu; Khemis, Jean; Kristensen, Nadj ...; Kuhn, Michael; Lejard, Véroniqu ...; Levenez, Florenc ...; Lucas-Martini, L ...; Massey, Robin; Maziers, Nicolas; Medina-Stamminge ...; Montalescot, Gil ...; Moutel, Sandrine; Le Pavin, Laetit ...; Poitou, Christin ...; Pousset, Francoi ...; Pouzoulet, Laure ...; Schmidt, Sebasti ...; Moitinho-Silva, ...; Silvain, Johanne; Sokolovska, Nata ...; Touch, Sothea; Svendstrup, Math ...; Swartz, Timothy; Vanduyvenboden, ...; Vatier, Camille; Walther, Stefani ...; Køber, Lars; Vestergaard, H.; Hansen, Torben; Zucker, Jean-Dan ...; Galan, Pilar; Dumas, Marc-Emma ...; Raes, Jeroen; Oppert, Jean-Mic ...; Letunic, Ivica; Nielsen, Jens B, ...; Bork, Peer; Ehrlich, Stanisl ...; Stumvoll, M.; Pedersen, O. B.; Aron-Wisneswky, ...; Clement, K.; Bäckhed, Fredrik ...; Bel Lassen, Py; Sonderskov, N. B ...; show less...

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