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Imidazole propionat...
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
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- Molinaro, Antonio (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Bel Lassen, Pierre (author)
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- Henricsson, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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show more...
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- Wu, Hao (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Adriouch, Solia (author)
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Belda, Eugeni (author)
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- Chakaroun, Rima (author)
- Universität Leipzig,Leipzig University
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- Nielsen, Trine (author)
- Köpenhamns universitet,University of Copenhagen
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- Bergh, Per-Olof (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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Rouault, Christine (author)
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André, Sébastien (author)
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Marquet, Florian (author)
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Andreelli, Fabrizio (author)
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- Salem, Joe-Elie (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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Assmann, Karen (author)
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- Bastard, Jean-Phillippe (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Forslund, Sofia K. (author)
- Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine
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- Le Chatelier, Emmanuelle (author)
- Université Paris-Saclay,University Paris-Saclay
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- Falony, Gwen (author)
- Katholieke Universiteit Leuven
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- Pons, Nicolas (author)
- Université Paris-Saclay,University Paris-Saclay
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- Prifti, Edi (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Quinquis, Benoit (author)
- Université Paris-Saclay,University Paris-Saclay
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- Roume, Hugo (author)
- Université Paris-Saclay,University Paris-Saclay
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- Vieira-Silva, Sara (author)
- Katholieke Universiteit Leuven
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- Hansen, Tue H. (author)
- Köpenhamns universitet,University of Copenhagen
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- Pedersen, Helle K. (author)
- Köpenhamns universitet,University of Copenhagen
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- Lewinter, Christian (author)
- Köpenhamns universitet,University of Copenhagen
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- Søndertoft, Nadja B. (author)
- Köpenhamns universitet,University of Copenhagen
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- Alves, Renato (author)
- European Molecular Biology Laboratory
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Amouyal, Chloe (author)
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- Galijatovic, Ehm Astrid Andersson (author)
- Köpenhamns universitet,University of Copenhagen
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- Barthelemy, Olivier (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Batisse, Jean-Paul (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Berland, Magalie (author)
- Université Paris-Saclay,University Paris-Saclay
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- Bittar, Randa (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Blottière, Hervé (author)
- Université Paris-Saclay,University Paris-Saclay
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- Bosquet, Frederic (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Boubrit, Rachid (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Bourron, Olivier (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Camus, Mickael (author)
- Université Paris-Saclay,University Paris-Saclay
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- Cassuto, Dominique (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Chilloux, J. (author)
- Imperial College of Science, Technology and Medicine
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- Ciangura, Cecile (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Coelho, Luis P. (author)
- European Molecular Biology Laboratory
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- Collet, Jean-Philippe (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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Dao, Maria-Carlota (author)
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- Djebbar, Morad (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Doré, Angélique (author)
- Université Paris-Saclay,University Paris-Saclay
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Engelbrechtsen, Line (author)
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- Fellahi, Soraya (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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Fezeu, Leopold (author)
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- Fromentin, Sebastien (author)
- Université Paris-Saclay,University Paris-Saclay
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- Giral, Philippe (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Gøtze, Jens P. (author)
- Köpenhamns universitet,University of Copenhagen
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- Hartemann, Agnes (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Holst, Jens Juul (author)
- Köpenhamns universitet,University of Copenhagen
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Hercberg, Serge (author)
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- Helft, Gerard (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Hornbak, Malene (author)
- Köpenhamns universitet,University of Copenhagen
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Hulot, Jean-Sébastien (author)
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- Isnard, Richard (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Jaqueminet, Sophie (author)
- Université Paris-Saclay,University Paris-Saclay
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- Jørgensen, Niklas Rye (author)
- Köpenhamns universitet,University of Copenhagen
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- Julienne, Hanna (author)
- Université Paris-Saclay,University Paris-Saclay
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- Justesen, Johanne (author)
- Köpenhamns universitet,University of Copenhagen
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- Kammer, Judith (author)
- Universität Leipzig,Leipzig University
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- Krarup, Nikolaj (author)
- Köpenhamns universitet,University of Copenhagen
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- Kerneis, Mathieu (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Khemis, Jean (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Kristensen, Nadja Buus (author)
- Köpenhamns universitet,University of Copenhagen
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- Kuhn, Michael (author)
- European Molecular Biology Laboratory
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- Lejard, Véronique (author)
- Université Paris-Saclay,University Paris-Saclay
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- Levenez, Florence (author)
- Université Paris-Saclay,University Paris-Saclay
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- Lucas-Martini, Lea (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Massey, Robin (author)
- Université Paris-Saclay,University Paris-Saclay
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- Maziers, Nicolas (author)
- Université Paris-Saclay,University Paris-Saclay
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- Medina-Stamminger, Jonathan (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Montalescot, Gilles (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Moutel, Sandrine (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Le Pavin, Laetitia Pasero (author)
- Université Paris-Saclay,University Paris-Saclay
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Poitou, Christine (author)
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- Pousset, Francoise (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Pouzoulet, Laurence (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Schmidt, Sebastian (author)
- European Molecular Biology Laboratory
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- Moitinho-Silva, Lucas (author)
- European Molecular Biology Laboratory
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- Silvain, Johanne (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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Sokolovska, Nataliya (author)
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Touch, Sothea (author)
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- Svendstrup, Mathilde (author)
- Köpenhamns universitet,University of Copenhagen
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Swartz, Timothy (author)
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- Vanduyvenboden, Thierry (author)
- Université Paris-Saclay,University Paris-Saclay
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- Vatier, Camille (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Walther, Stefanie (author)
- Universität Leipzig,Leipzig University
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- Køber, Lars (author)
- Köpenhamns universitet,University of Copenhagen
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- Vestergaard, H. (author)
- Köpenhamns universitet,University of Copenhagen
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- Hansen, Torben (author)
- Köpenhamns universitet,University of Copenhagen
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- Zucker, Jean-Daniel (author)
- UMMISCO
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Galan, Pilar (author)
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- Dumas, Marc-Emmanuel (author)
- Imperial College of Science, Technology and Medicine
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- Raes, Jeroen (author)
- Université Paris-Saclay,University Paris-Saclay
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- Oppert, Jean-Michel (author)
- Assistance publique – Hôpitaux de Paris (AP-HP)
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- Letunic, Ivica (author)
- Biobyte Solutions GmbH
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Bork, Peer (author)
- European Molecular Biology Laboratory
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- Ehrlich, Stanislav Dusko (author)
- Université Paris-Saclay,University Paris-Saclay
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- Stumvoll, M. (author)
- Universität Leipzig,Leipzig University
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- Pedersen, O. B. (author)
- Köpenhamns universitet,University of Copenhagen
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Aron-Wisneswky, Judith (author)
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Clement, K. (author)
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- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
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Bel Lassen, Py (author)
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Sonderskov, N. B. (author)
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(creator_code:org_t)
- 2020-11-18
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 11:1
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- homeostasis model assessment
- intestinal microbiota
- insulin
- sensitivity
- accurate method
- gut microbiome
- glucose
- individuals
- risk
- metagenome
- physiology
- Science & Technology - Other Topics
Publication and Content Type
- art (subject category)
- ref (subject category)
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Molinaro, Antoni ...
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Bel Lassen, Pier ...
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Henricsson, Marc ...
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Wu, Hao
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Adriouch, Solia
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Belda, Eugeni
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show more...
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Chakaroun, Rima
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Nielsen, Trine
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Bergh, Per-Olof
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Rouault, Christi ...
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André, Sébastien
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Marquet, Florian
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Andreelli, Fabri ...
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Salem, Joe-Elie
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Assmann, Karen
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Bastard, Jean-Ph ...
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Forslund, Sofia ...
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Le Chatelier, Em ...
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Falony, Gwen
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Pons, Nicolas
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Prifti, Edi
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Quinquis, Benoit
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Roume, Hugo
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Vieira-Silva, Sa ...
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Hansen, Tue H.
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Pedersen, Helle ...
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Lewinter, Christ ...
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Søndertoft, Nadj ...
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Alves, Renato
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Amouyal, Chloe
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Galijatovic, Ehm ...
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Barthelemy, Oliv ...
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Batisse, Jean-Pa ...
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Berland, Magalie
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Bittar, Randa
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Blottière, Hervé
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Bosquet, Frederi ...
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Boubrit, Rachid
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Bourron, Olivier
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Camus, Mickael
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Cassuto, Dominiq ...
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Chilloux, J.
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Ciangura, Cecile
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Coelho, Luis P.
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Collet, Jean-Phi ...
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Dao, Maria-Carlo ...
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Djebbar, Morad
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Doré, Angélique
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Engelbrechtsen, ...
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Fellahi, Soraya
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Fezeu, Leopold
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Fromentin, Sebas ...
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Giral, Philippe
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Gøtze, Jens P.
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Hartemann, Agnes
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Holst, Jens Juul
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Hercberg, Serge
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Helft, Gerard
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Hornbak, Malene
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Hulot, Jean-Séba ...
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Isnard, Richard
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Jaqueminet, Soph ...
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Jørgensen, Nikla ...
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Julienne, Hanna
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Justesen, Johann ...
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Kammer, Judith
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Krarup, Nikolaj
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Kerneis, Mathieu
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Khemis, Jean
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Kristensen, Nadj ...
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Kuhn, Michael
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Lejard, Véroniqu ...
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Levenez, Florenc ...
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Lucas-Martini, L ...
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Massey, Robin
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Maziers, Nicolas
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Medina-Stamminge ...
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Montalescot, Gil ...
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Moutel, Sandrine
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Le Pavin, Laetit ...
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Poitou, Christin ...
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Pousset, Francoi ...
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Pouzoulet, Laure ...
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Schmidt, Sebasti ...
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Moitinho-Silva, ...
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Silvain, Johanne
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Sokolovska, Nata ...
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Touch, Sothea
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Svendstrup, Math ...
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Swartz, Timothy
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Vanduyvenboden, ...
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Vatier, Camille
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Walther, Stefani ...
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Køber, Lars
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Vestergaard, H.
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Hansen, Torben
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Zucker, Jean-Dan ...
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Galan, Pilar
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Dumas, Marc-Emma ...
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Raes, Jeroen
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Oppert, Jean-Mic ...
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Letunic, Ivica
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Nielsen, Jens B, ...
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Bork, Peer
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Ehrlich, Stanisl ...
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Stumvoll, M.
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Pedersen, O. B.
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Aron-Wisneswky, ...
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Clement, K.
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Bäckhed, Fredrik ...
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Bel Lassen, Py
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Sonderskov, N. B ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Nature Communica ...
- By the university
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Chalmers University of Technology
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University of Gothenburg