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Natural green coati...
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Trentin, Danielle S
(author)
Natural green coating inhibits adhesion of clinically important bacteria
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-02-06
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Nature Publishing Group,2015
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-100278
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100278URI
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https://doi.org/10.1038/srep08287DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Despite many advances, biomaterial-associated infections continue to be a major clinical problem. In order to minimize bacterial adhesion, material surface modifications are currently being investigated and natural products possess large potential for the design of innovative surface coatings. We report the bioguided phytochemical investigation of Pityrocarpa moniliformis and the characterization of tannins by mass spectrometry. It was demonstrated that B-type linked proanthocyanidins-coated surfaces, here termed Green coatings, reduced Gram-positive bacterial adhesion and supported mammalian cell spreading. The proposed mechanism of bacterial attachment inhibition is based on electrostatic repulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-substratum interactions. This work shows the applicability of a prototype Green-coated surface that aims to promote necessary mammalian tissue compatibility, while reducing bacterial colonization.
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Silva, Denise B
(author)
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Frasson, Amanda P
(author)
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Rzhepishevska, OlenaUmeå universitet,Kemiska institutionen(Swepub:umu)olrz0001
(author)
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da Silva, Márcia V
(author)
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Pulcini, Elinor de L
(author)
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James, Garth
(author)
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Soares, Gabriel V
(author)
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Tasca, Tiana
(author)
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Ramstedt, MadeleineUmeå universitet,Kemiska institutionen(Swepub:umu)maerat95
(author)
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Giordani, Raquel B
(author)
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Lopes, Norberto P
(author)
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Macedo, Alexandre J
(author)
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Umeå universitetKemiska institutionen
(creator_code:org_t)
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In:Scientific Reports: Nature Publishing Group5, s. 8287-2045-2322
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James, Garth
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