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Sökning: WFRF:(Child J) > (2015-2019) > Investigating a nov...

  • Hill, Y.R.King's College London (författare)

Investigating a novel activation-repolarisation time metric to predict localised Vulnerability to reentry using computational modelling

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-03-02
  • Public Library of Science (PLoS),2016

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:93e78f68-4584-419d-b5f7-f0ddd823b1e8
  • https://research.chalmers.se/publication/236306URI
  • https://doi.org/10.1371/journal.pone.0149342DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • © 2016 Hill et al. Exit sites associated with scar-related reentrant arrhythmias represent important targets for catheter ablation therapy. However, their accurate location in a safe and robust manner remains a significant clinical challenge. We recently proposed a novel quantitative metric (termed the Reentry Vulnerability Index, RVI) to determine the difference between activation and repolarisation intervals measured from pairs of spatial locations during premature stimulation to accurately locate the critical site of reentry formation. In the clinic, the method showed potential to identify regions of low RVI corresponding to areas vulnerable to reentry, subsequently identified as ventricular tachycardia (VT) circuit exit sites. Here, we perform an in silico investigation of the RVI metric in order to aid the acquisition and interpretation of RVI maps and optimise its future usage within the clinic. Within idealised 2D sheet models we show that the RVI produces lower values under correspondingly more arrhythmogenic conditions, with even low resolution (8 mm electrode separation) recordings still able to locate vulnerable regions. When applied to models of infarct scars, the surface RVI maps successfully identified exit sites of the reentrant circuit, even in scenarios where the scar was wholly intramural. Within highly complex infarct scar anatomies with multiple reentrant pathways, the identified exit sites were dependent upon the specific pacing location used to compute the endocardial RVI maps. However, simulated ablation of these sites successfully prevented the reentry re-initiation. We conclude that endocardial surface RVI maps are able to successfully locate regions vulnerable to reentry corresponding to critical exit sites during sustained scar-related VT. The method is robust against highly complex and intramural scar anatomies and low resolution clinical data acquisition. Optimal location of all relevant sites requires RVI maps to be computed from multiple pacing locations. Copyright:

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Child, N.King's College London (författare)
  • Hanson, B.University College London (UCL) (författare)
  • Wallman, Mikael,1979Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC)(Swepub:cth)mikwal (författare)
  • Coronel, R.Université de Bordeaux,University of Bordeaux,Universiteit Van Amsterdam,University of Amsterdam (författare)
  • Plank, G.Medizinische Universität Graz,Medical University of Graz (författare)
  • Rinaldi, C.A.Guy's and St Thomas' NHS Foundation Trust (författare)
  • Gill, J.Guy's and St Thomas' NHS Foundation Trust (författare)
  • Smith, N.P.King's College London,University of Auckland (författare)
  • Taggart, P.University College London (UCL) (författare)
  • Bishop, M.J.King's College London (författare)
  • King's College LondonUniversity College London (UCL) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLoS ONE: Public Library of Science (PLoS)11:31932-62031932-6203

Internetlänk

Hitta via bibliotek

  • PLoS ONE (Sök värdpublikationen i LIBRIS)

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