Search: WFRF:(Trost M)
> (2020-2024) >
Type 2 diabetes is ...
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
-
- Mikkelsen, Randi Bonke (author)
- Köpenhamns universitet,University of Copenhagen
-
- Arora, Tulika (author)
- Köpenhamns universitet,University of Copenhagen
-
- Trošt, Kajetan (author)
- Köpenhamns universitet,University of Copenhagen
-
show more...
-
- Dmytriyeva, Oksana (author)
- Köpenhamns universitet,University of Copenhagen
-
- Jensen, Sune Kjærsgaard (author)
- Köpenhamns universitet,University of Copenhagen
-
- Meijnikman, A. S. (author)
- Universiteit Van Amsterdam,University of Amsterdam
-
- Olofsson, Louise, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
-
- Lappa, Dimitra, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Aydin, O. (author)
- Universiteit Van Amsterdam,University of Amsterdam
-
- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Gerdes, V. E.A. (author)
- Universiteit Van Amsterdam,University of Amsterdam
-
- Moritz, Thomas (author)
- Köpenhamns universitet,University of Copenhagen
-
- Van de Laar, A. W. (author)
- Spaarne Gasthuis,Spaarne Hospital
-
- de Brauw, Maurits (author)
- Spaarne Gasthuis,Spaarne Hospital
-
- Nieuwdorp, M. (author)
- Universiteit Van Amsterdam,University of Amsterdam
-
- Hjorth, S. (author)
- Köpenhamns universitet,University of Copenhagen
-
- Schwartz, Thue W. (author)
- Köpenhamns universitet,University of Copenhagen
-
- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
-
In: iScience. - : Elsevier BV. - 2589-0042. ; 25:12
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
https://research.cha...
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- Obesity and diabetes are associated with inflammation and altered plasma levels of several metabolites, which may be involved in disease progression. Some metabolites can activate G protein-coupled receptors (GPCRs) expressed on immune cells where they can modulate metabolic inflammation. Here, we find that 3-hydroxydecanoate is enriched in the circulation of obese individuals with type 2 diabetes (T2D) compared with nondiabetic controls. Administration of 3-hydroxydecanoate to mice promotes immune cell recruitment to adipose tissue, which was associated with adipose inflammation and increased fasting insulin levels. Furthermore, we demonstrate that 3-hydroxydecanoate stimulates migration of primary human and mouse neutrophils, but not monocytes, through GPR84 and Gαi signaling in vitro. Our findings indicate that 3-hydroxydecanoate is a T2D-associated metabolite that increases inflammatory responses and may contribute to the chronic inflammation observed in diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Cell biology
- Pathophysiology
- Immunology
- Cell biology
- Immunology
- Pathophysiology
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
iScience
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Mikkelsen, Randi ...
-
Arora, Tulika
-
Trošt, Kajetan
-
Dmytriyeva, Oksa ...
-
Jensen, Sune Kjæ ...
-
Meijnikman, A. S ...
-
show more...
-
Olofsson, Louise ...
-
Lappa, Dimitra, ...
-
Aydin, O.
-
Nielsen, Jens B, ...
-
Gerdes, V. E.A.
-
Moritz, Thomas
-
Van de Laar, A. ...
-
de Brauw, Maurit ...
-
Nieuwdorp, M.
-
Hjorth, S.
-
Schwartz, Thue W ...
-
Bäckhed, Fredrik ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
iScience
- By the university
-
Chalmers University of Technology
-
University of Gothenburg