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- Blockhuys, Stephanie,1983Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Chalmers, Sweden (author)
X-radiation enhances the collagen type I strap formation and migration potentials of colon cancer cells
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-09-19
- Impact Journals, LLC,2016
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:research.chalmers.se:9844f7e0-93e9-4778-957e-7015dfbed637
- https://doi.org/10.18632/oncotarget.12111DOI
- https://research.chalmers.se/publication/246017URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133003URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Funding Agencies|Swedish Cancer Foundation; Swedish Research Council; Wallenberg Foundation; Health Research Council in South-East Sweden
- Rectal cancer treatment still fails with local and distant relapses of the disease. It is hypothesized that radiotherapy could stimulate cancer cell dissemination and metastasis. In this study, we evaluated the effect of X-radiation on collagen type I strap formation potential, i.e. matrix remodeling associated with mesenchymal cell migration, and behaviors of SW480, SW620, HCT116 p53(+/+) and HCT116 p53(-/-) colon cancer cells. We determined a radiation-induced increase in collagen type I strap formation and migration potentials of SW480 and HCT116 p53(+/+). Further studies with HCT116 p53(+/+), indicated that after X-radiation strap forming cells have an increased motility. More, we detected a decrease in adhesion potential and mature integrin beta 1 expression, but no change in non-muscle myosin II expression for HCT116 p53(+/+) after X-radiation. Integrin beta 1 neutralization resulted in a decreased cell adhesion and collagen type I strap formation in both sham and X-radiated conditions. Our study indicates collagen type I strap formation as a potential mechanism of colon cancer cells with increased migration potential after X-radiation, and suggests that other molecules than integrin beta 1 and non-muscle myosin II are responsible for the radiation-induced collagen type I strap formation potential of colon cancer cells. This work encourages further molecular investigation of radiation-induced migration to improve rectal cancer treatment outcome.
Subject headings and genre
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- matrix contraction
- X-radiation
- integrin beta 1
- p53
- Cell Biology
- radiotherapy
- colorectal cancer
- nonmuscle myosin-ii
- growth-factor
- collagen type 1
- cell migration
- Oncology
- metastasis
- reorganization
- invasion
Added entries (persons, corporate bodies, meetings, titles ...)
- Liu, NaLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)nali27 (author)
- Agarwal, Nisha Rani,1987Chalmers tekniska högskola,Chalmers University of Technology,Chalmers, Sweden(Swepub:cth)agarwal (author)
- Enejder, Annika,1969Chalmers tekniska högskola,Chalmers University of Technology,Chalmers, Sweden(Swepub:cth)enejder (author)
- Loitto, VesaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)veslo07 (author)
- Sun, Xiao-FengLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
- Linköpings universitetAvdelningen för kliniska vetenskaper (creator_code:org_t)
Related titles
- In:Oncotarget: Impact Journals, LLC7:44, s. 71390-713991949-2553
Internet link
- http://dx.doi.org/10.18632/oncotarget.12111FULLTEXT
- https://research.chalmers.se/publication/246017/file/246017_Fulltext.pdfFULLTEXT
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12111&path%5B%5D=38324
- https://liu.diva-portal.org/smash/get/diva2:1054699/FULLTEXT01.pdffulltext:print
- https://doi.org/10.18632/oncotarget.12111
- https://research.chalmers.se/publication/246017
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133003
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