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  • Achcar, F.University of Glasgow (author)

The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Elsevier,2014
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:9a4e28fd-92e5-4644-94a9-15554ed996b8
  • ISBN:9780128001431
  • https://research.chalmers.se/publication/201828URI
  • https://doi.org/10.1016/b978-0-12-800143-1.00003-8DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:kap swepub-publicationtype
  • Subject category:vet swepub-contenttype

Notes

  • The African trypanosome, Ttypanosoma brucei, is a unicellular parasite causing African Trypanosomiasis (sleeping sickness in humans and nagana in animals). Due to some of its unique properties, it has emerged as a popular model organism in systems biology. A predictive quantitative model of glycolysis in the bloodstream form of the parasite has been constructed and updated several times. The Silicon Trypanosome is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation. These new extensions and analyses use computational methods that explicitly take different levels of uncertainty into account. During this project, numerous tools and techniques have been developed for this purpose, which can now be used for a wide range of different studies in systems biology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fadda, A.Ruprecht-Karls-Universität Heidelberg,Heidelberg University (author)
  • Haanstra, J. R.Rijksuniversiteit Groningen,University of Groningen,Vrije Universiteit Amsterdam (VU) (author)
  • Kerkhoven, Eduard,1985Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)eduardk (author)
  • Kim, D. H.Wellcome Trust Centre for Molecular Parasitology (author)
  • Leroux, A. E.Ruprecht-Karls-Universität Heidelberg,Heidelberg University (author)
  • Papamarkou, T.University College London (UCL) (author)
  • Rojas, F.University of Edinburgh (author)
  • Bakker, B.M.Rijksuniversiteit Groningen,University of Groningen (author)
  • Barrett, M. P.Wellcome Trust Centre for Molecular Parasitology (author)
  • Clayton, C.Ruprecht-Karls-Universität Heidelberg,Heidelberg University (author)
  • Girolami, M.University College London (UCL) (author)
  • Krauth-Siegel, R. L.Ruprecht-Karls-Universität Heidelberg,Heidelberg University (author)
  • Matthews, K. R.University of Edinburgh (author)
  • Breitling, R.University of Manchester (author)
  • University of GlasgowRuprecht-Karls-Universität Heidelberg (creator_code:org_t)

Related titles

  • In:Advances in Microbial Physiology: Elsevier64, s. 115-1430065-29119780128001431

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