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Sökning: WFRF:(Choi Jin Young) > (2020-2024) > Early increment of ...

  • Kwon, Hyuk SungHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)

Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • ELSEVIER SCI LTD,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-411437
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-411437URI
  • https://doi.org/10.1016/j.jocn.2020.02.016DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lee, Eun-HyeHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea. (författare)
  • Park, Hyun-HeeHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Jin, Jeong-HwaHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Choi, HojinHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Lee, Kyu-YongHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Lee, Young JooHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Lee, Jae-HongUniv Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • de Oliveira, Felipe Marques SouzaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)felma546 (författare)
  • Kim, Hyun YoungHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Kim, Young SeoHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Kim, Bum JoonKyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Heo, Sung HyukKyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Chang, Dae-IlKyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea. (författare)
  • Kamali-Moghaddam, MasoodUppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab(Swepub:uu)masookam (författare)
  • Koh, Seong-HoHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea. (författare)
  • Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of clinical neuroscience: ELSEVIER SCI LTD73, s. 215-2180967-58681532-2653

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