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> (2020-2024) >
Early increment of ...
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Kwon, Hyuk SungHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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ELSEVIER SCI LTD,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-411437
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-411437URI
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https://doi.org/10.1016/j.jocn.2020.02.016DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lee, Eun-HyeHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea.
(författare)
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Park, Hyun-HeeHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Jin, Jeong-HwaHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Choi, HojinHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Lee, Kyu-YongHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Lee, Young JooHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Lee, Jae-HongUniv Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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de Oliveira, Felipe Marques SouzaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)felma546
(författare)
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Kim, Hyun YoungHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Kim, Young SeoHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Kim, Bum JoonKyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Heo, Sung HyukKyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Chang, Dae-IlKyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea.
(författare)
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Kamali-Moghaddam, MasoodUppsala universitet,Molekylära verktyg,Science for Life Laboratory, SciLifeLab(Swepub:uu)masookam
(författare)
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Koh, Seong-HoHanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea.
(författare)
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Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.Hanyang Univ, Dept Neurol, Coll Med, Seoul, South Korea.;Hanyang Univ, Dept Translat Med, Grad Sch Biomed Sci & Engn, Seoul, South Korea.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of clinical neuroscience: ELSEVIER SCI LTD73, s. 215-2180967-58681532-2653
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Till lärosätets databas
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Kwon, Hyuk Sung
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Lee, Eun-Hye
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Park, Hyun-Hee
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Jin, Jeong-Hwa
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Choi, Hojin
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Lee, Kyu-Yong
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visa fler...
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Lee, Young Joo
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Lee, Jae-Hong
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de Oliveira, Fel ...
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Kim, Hyun Young
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Kim, Young Seo
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Kim, Bum Joon
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Heo, Sung Hyuk
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Chang, Dae-Il
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Kamali-Moghaddam ...
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Koh, Seong-Ho
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Uppsala universitet