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Search: (WFRF:(Kim H. S.)) srt2:(1991-1994) > PNA HYBRIDIZES TO C...

  • Egholm, M. (author)

PNA HYBRIDIZES TO COMPLEMENTARY OLIGONUCLEOTIDES OBEYING THE WATSON-CRICK HYDROGEN-BONDING RULES

  • Article/chapterEnglish1993

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,1993

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:a0e398d4-531d-464e-a942-1f71f89e96e1
  • https://research.chalmers.se/publication/144347URI
  • https://doi.org/10.1038/365566a0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • DNA ANALOGUES are currently being intensely investigated owing to their potential as gene-targeted drugs1-3. Furthermore, their properties and interaction with DNA and RNA could provide a better understanding of the structural features of natural DNA that determine its unique chemical, biological and genetic properties3,4. We recently designed a DNA analogue, PNA, in which the backbone is structurally homomorphous with the deoxyribose backbone and consists of N-(2-aminoethyl)glycine units to which the nucleobases are attached5-9. We showed that PNA oligomers containing solely thymine and cytosine can hybridize to complementary oligonucleotides, presumably by forming Watson-Crick-Hoogsteen (PNA)2-DNA triplexes, which are much more stable than the corresponding DNA-DNA duplexes5-7, and bind to double-stranded DNA by strand displacement5,8. We report here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the Watson-Crick base-pairing rules, and thus is a true DNA mimic in terms of base-pair recognition.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Buchardt, O. (author)
  • Christensen, L. (author)
  • Behrens, C. (author)
  • Freier, S. M. (author)
  • Driver, D. A. (author)
  • Berg, R. H. (author)
  • Kim, Seog K.Chalmers tekniska högskola,Chalmers University of Technology (author)
  • Nordén, Bengt,1945Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)norden (author)
  • Nielsen, P. E. (author)
  • Chalmers tekniska högskola (creator_code:org_t)

Related titles

  • In:Nature: Springer Science and Business Media LLC365:6446, s. 566-5680028-08361476-4687

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