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  • Mancusi, Davide,1980Chalmers tekniska högskola,Chalmers University of Technology (författare)

Calculation of Energy-Deposition Distributions and Microdosimetric Estimation of the Biological Effect of a 9C Beam

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • 2009

Nummerbeteckningar

  • LIBRIS-ID:oai:research.chalmers.se:a4be3a94-773e-411a-9401-fdfe2740a88a
  • https://research.chalmers.se/publication/111285URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Among the alternative beams being recently considered for external cancer radiotherapy, C-9 has received some attention because it is expected that its biological effectiveness could be boosted by the beta-delayed emission of two alpha particles and a proton that takes place at the ion-stopping site. Experiments have been performed to characterise this exotic beam physically and models have been developed to estimate quantitatively its biological effect. Here, the particle and heavy-ion transport code system (PHITS ) is used to calculate energy-deposition and linear energy transfer distributions for a C-9 beam in water and the results are compared with published data. Although PHITS fails to reproduce some of the features of the distributions, it suggests that the decay of C-9 contributes negligibly to the energy-deposition distributions, thus contradicting the previous interpretation of the measured data. We have also performed a microdosimetric calculation to estimate the biological effect of the decay, which was found to be negligible; previous microdosimetric Monte-Carlo calculations were found to be incorrect. An analytical argument, of geometrical nature, confirms this conclusion and gives a theoretical upper bound on the additional biological effectiveness of the decay. However, no explanation can be offered at present for the observed difference in the biological effectiveness between C-9 and C-12; the reproducibility of this surprising result will be verified in coming experiments.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sihver, Lembit,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)sihver (författare)
  • Niita, K. (författare)
  • Li, Q (författare)
  • Sato, T. (författare)
  • Iwase, H. (författare)
  • Iwamoto, Y. (författare)
  • Matsuda, N. (författare)
  • Sakamoto, Y. (författare)
  • Nakashima, H. (författare)
  • Chalmers tekniska högskola (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Radiation and Environmental Biophysics48:2, s. 135-1431432-20990301-634X

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