Sökning: WFRF:(Ji Boyang 1983)
> (2023) >
Whole-genome sequen...
Whole-genome sequencing reveals high-risk clones of Pseudomonas aeruginosa in Guangdong, China
-
- Zhao, Yonggang (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark
-
- Chen, Dingqiang (författare)
- Southern Medical University
-
- Ji, Boyang, 1983 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
visa fler...
-
- Zhang, Xingju (författare)
- BGI Institute of Applied Agriculture
-
- Anbo, Mikkel (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark
-
- Jelsbak, Lars (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Frontiers in Microbiology. - 1664-302X. ; 14
- Relaterad länk:
-
https://research.cha... (primary) (free)
-
visa fler...
-
https://research.cha...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The ever-increasing prevalence of infections produced by multidrug-resistant or extensively drug-resistant Pseudomonas aeruginosa is commonly linked to a limited number of aptly-named epidemical 'high-risk clones' that are widespread among and within hospitals worldwide. The emergence of new potential high-risk clone strains in hospitals highlights the need to better and further understand the underlying genetic mechanisms for their emergence and success. P. aeruginosa related high-risk clones have been sporadically found in China, their genome sequences have rarely been described. Therefore, the large-scale sequencing of multidrug-resistance high-risk clone strains will help us to understand the emergence and transmission of antibiotic resistances in P. aeruginosa high-risk clones. In this study, 212 P. aeruginosa strains were isolated from 2 tertiary hospitals within 3 years (2018-2020) in Guangdong Province, China. Whole-genome sequencing, multi-locus sequence typing (MLST) and antimicrobial susceptibility testing were applied to analyze the genomic epidemiology of P. aeruginosa in this region. We found that up to 130 (61.32%) of the isolates were shown to be multidrug resistant, and 196 (92.45%) isolates were Carbapenem-Resistant Pseudomonas aeruginosa. MLST analysis demonstrated high diversity of sequence types, and 18 reported international high-risk clones were identified. Furthermore, we discovered the co-presence of exoU and exoS genes in 5 collected strains. This study enhances insight into the regional research of molecular epidemiology and antimicrobial resistance of P. aeruginosa in China. The high diversity of clone types and regional genome characteristics can serve as a theoretical reference for public health policies and help guide measures for the prevention and control of P. aeruginosa resistance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- carbapenem resistant
- Pseudomonas aeruginosa
- high-risk clone
- multidrug resistance
- genomic epidemiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas