A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers

• The electrocardiogram (ECG) is often used to diag-nose myocardial infarction, but sensitivity and specificityare low. Here we present a computational framework forsolving the bidomain equations over an image-based hu-man geometry and simulating the 12 lead ECG. First, wedemonstrate this approach by evaluating a population ofeight models with varying distributions of local action po-tential duration, and report that only the model with apico-basal and inter-ventricular heterogeneities produces con-cordant T waves. Second, we simulate the effects of anold anterior infarct, which causes a reduction in T waveamplitude and width. Our methodology can contribute tothe understanding of ECG alterations under challengingconditions for clinical diagnosis.

Ämnesord

NATURVETENSKAP  -- Matematik -- Beräkningsmatematik (hsv//swe)

NATURAL SCIENCES  -- Mathematics -- Computational Mathematics (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences (hsv//eng)

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