Ambivalent Intercalators for DNA: L-Shaped Platinum(II) Complexes

Nordén, Bengt,1945Chalmers tekniska högskola,Chalmers University of Technology (författare)

Novel platinum(II) square planar coordination complexes, in which two heteroaromatic ligands are held by the metal in an unusual L-shaped geometry orthogonal to each other, have been synthesized, and their interaction with DNA was investigated with absorption and linear dichroism spectroscopy. As a rule, the ligand that is coplanar with the coordination square of Pt is found to be oriented perpendicular relative to the DNA helix axis when bound, suggestive of its intercalation between the base pairs of DNA. However, when this coplanar ligand is replaced by two pyridines, the opposite ligand, orthogonal to the coordination square, is instead preferentially intercalated. This behavior shows that these new complexes do indeed show some properties of true ambintercalators, i.e., compounds that can bind by intercalation of either of two distinct aromatic moieties.

Lincoln, Per,1958Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)lincoln (författare)
Cusumano, MatteoUniversita degli Studi di Messina,University of Messina (författare)
Pietro, Maria Letizia DiUniversita degli Studi di Messina,University of Messina (författare)
Nordén, Bengt,1945Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)norden (författare)
Lincoln, Per,1958Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)lincoln (författare)
Chalmers tekniska högskolaUniversita degli Studi di Messina (creator_code:org_t)

Ingår i:Inorganic Chemistry: American Chemical Society (ACS)43:7, s. 2416-24210020-16691520-510X

Av författaren/redakt...: Nordén, Bengt, 1 ...; Lincoln, Per, 19 ...; Cusumano, Matteo; Pietro, Maria Le ...

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