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Nitrogen as the maj...
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Hapeta, PiotrWroclaw University of Environmental and Life Sciences
(författare)
Nitrogen as the major factor influencing gene expression in Yarrowia lipolytica
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Elsevier BV,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:a9a57663-97ea-4df3-96e7-701e0070c763
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https://research.chalmers.se/publication/518876URI
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https://doi.org/10.1016/j.btre.2020.e00521DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Yarrowia lipolytica is an important industrial microorganism used for the production of oleochemicals. The design of effective biotechnological processes with this cell factory requires an in-depth knowledge of its metabolism. Here we present a transcriptomic study of Y. lipolytica grown in the presence of glycerol and glucose, and mixture of both at different carbon to nitrogen ratios. It emerged that the transcriptomic landscape of Y. lipolytica is more sensitive to the nitrogen availability than to the utilized carbon source, as evidenced by more genes being differentially expressed in lower carbon to nitrogen ratio. Specifically, expression of hexokinase (HXK1) is significantly susceptible to changes in nitrogen concentrations. High HXK1 expression in low nitrogen seems to impact other genes which are implicated in tricarboxylic acid cycle and erythritol biosynthesis. We further show that expression of HXK1 and two genes belonging to the sugar porter family might be controlled by GATA-like zinc-finger proteins.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kerkhoven, Eduard,1985Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)eduardk
(författare)
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Lazar, ZbigniewWroclaw University of Environmental and Life Sciences
(författare)
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Wroclaw University of Environmental and Life SciencesNovo Nordisk Fonden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biotechnology Reports: Elsevier BV272215-017X
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