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- Maury, J.Danmarks Tekniske Universitet,Technical University of Denmark (author)
Metabolic engineering of isoprenoid production: Reconstruction of multistep heterologous pathways in tractable hosts
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2012-08-22
- New York, NY :Springer New York,2013
Numbers
- LIBRIS-ID:oai:research.chalmers.se:ac7f7d8c-0d67-4a23-a7ed-b72480407667
- ISBN:9781461440635
- https://doi.org/10.1007/978-1-4614-4063-5_6DOI
- https://research.chalmers.se/publication/236154URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Isoprenoids represent a wide group of chemically active compounds that can find a wide range of applications as flavors, perfumes, vitamins, nutraceuticals, and pharmaceuticals. Many isoprenoids are naturally produced in very low quantities by plants, which make their use in broader perspectives difficult. Microbial production of plant-originating isoprenoids quickly appeared as an alternative of choice. Metabolic engineering methods were applied and proved successful to improve the supply of precursors to derive toward isoprenoid compounds of interest. Combinations between metabolic engineering and the flourishing field of synthetic biology have also been observed with researchers attempting to reconstruct and optimize complex biosynthetic pathways in well-characterized and tractable microbial hosts. In this chapter, we review recent metabolic engineering studies for isoprenoid production in yeast and try to show, through key examples, that the fields of synthetic biology and metabolic engineering can go hand in hand to establish microbial cell factories for isoprenoid production.
Subject headings and genre
- NATURVETENSKAP Biologi Bioinformatik och systembiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Bioinformatics and Systems Biology hsv//eng
- MEP pathway
- Heterologous gene
- Synthetic biology
- Metabolic engineering
- Mevalonate pathway
- Yeast
- Saccharomyces cerevisiae
Added entries (persons, corporate bodies, meetings, titles ...)
- Asadollahi, M. A.Danmarks Tekniske Universitet,Technical University of Denmark (author)
- Formenti, L. R.Danmarks Tekniske Universitet,Technical University of Denmark (author)
- Michel, S. (author)
- Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
- Danmarks Tekniske UniversitetChalmers tekniska högskola (creator_code:org_t)
Related titles
- In:Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental ApproachesNew York, NY : Springer New York, s. 73-899781461440635
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