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Cold-stimulated bro...
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD + metabolism in humans
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- U-Din, Mueez (author)
- Turun Yliopisto,University of Turku
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- de Mello, Vanessa D. (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Tuomainen, Marjo (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Raiko, Juho (author)
- Turun Yliopisto,University of Turku
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- Niemi, Tarja (author)
- Turun Yliopisto,University of Turku
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- Fromme, Tobias (author)
- Technische Universität München (TUM),Technical University of Munich (TUM)
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- Klåvus, Anton (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Gautier, Nadine (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Haimilahti, Kimmo (author)
- Helsingin Yliopisto,University of Helsinki
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- Lehtonen, Marko (author)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Kristiansen, Karsten (author)
- Köpenhamns universitet,University of Copenhagen
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- Newman, John W. (author)
- University of California
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- Pietilainen, K. H. (author)
- Helsinki University Central Hospital,Helsingin Yliopisto,University of Helsinki
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- Pihlajamäki, Jussi (author)
- Kuopio University Hospital,Itä-Suomen Yliopisto,University of Eastern Finland
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- Amri, Ez Zoubir (author)
- Université Côte d'Azur,University of Côte d'Azur
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- Klingenspor, Martin (author)
- Technische Universität München (TUM),Technical University of Munich (TUM)
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- Nuutila, Pirjo (author)
- Turun Yliopisto,University of Turku
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- Pirinen, Eija (author)
- Helsingin Yliopisto,University of Helsinki,Oulun Yliopisto,University of Oulu
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- Hanhineva, Kati, 1972 (author)
- Itä-Suomen Yliopisto,University of Eastern Finland,Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku
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- Virtanen, Kirsi A. (author)
- Turun Yliopisto,University of Turku,Kuopio University Hospital,Itä-Suomen Yliopisto,University of Eastern Finland
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Cell Reports. - 2211-1247. ; 42:9
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- BAT
- nicotinamide
- CP: Metabolism
- tryptophan
- human brown adipose tissue
- cold exposure
- NAD
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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U-Din, Mueez
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de Mello, Vaness ...
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Tuomainen, Marjo
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Raiko, Juho
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Niemi, Tarja
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Fromme, Tobias
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show more...
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Klåvus, Anton
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Gautier, Nadine
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Haimilahti, Kimm ...
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Lehtonen, Marko
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Kristiansen, Kar ...
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Newman, John W.
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Pietilainen, K. ...
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Pihlajamäki, Jus ...
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Amri, Ez Zoubir
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Klingenspor, Mar ...
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Nuutila, Pirjo
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Pirinen, Eija
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Hanhineva, Kati, ...
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Virtanen, Kirsi ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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Chalmers University of Technology