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SAXS imaging reveal...
SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model
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- Casanova, Elisa A. (author)
- Universitätsspital Zürich,University Hospital of Zürich
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- Rodriguez Palomo, Adrian, 1992 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Stähli, Lisa (author)
- Universitätsspital Zürich,University Hospital of Zürich
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- Arnke, Kevin (author)
- Universitätsspital Zürich,University Hospital of Zürich
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- Gröninger, Olivier (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Generali, Melanie (author)
- Universität Zürich,University of Zürich
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- Neldner, Yvonne (author)
- Universitätsspital Zürich,University Hospital of Zürich
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- Tiziani, Simon (author)
- Universitätsspital Zürich,University Hospital of Zürich
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- Dominguez, Ana Perez (author)
- Universität Zürich,University of Zürich
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- Guizar-Sicairos, Manuel (author)
- Paul Scherrer Institut
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- Gao, Zirui (author)
- Paul Scherrer Institut
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- Appel, Christian (author)
- Paul Scherrer Institut
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- Nielsen, Leonard, 1992 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Georgiadis, Marios (author)
- Stanford University
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- Weber, Franz E. (author)
- Universität Zürich,University of Zürich
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- Stark, Wendelin (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
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- Pape, Hans Christoph (author)
- Universitätsspital Zürich,University Hospital of Zürich
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- Cinelli, Paolo (author)
- Universität Zürich,University of Zürich,Universitätsspital Zürich,University Hospital of Zürich
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- Liebi, Marianne, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Eidgenössische Materialprüfungs- und Forschungsanstalt (Empa),Swiss Federal Laboratories for Materials Science and Technology (Empa)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 294
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Healing large bone defects remains challenging in orthopedic surgery and is often associated with poor outcomes and complications. A major issue with bioengineered constructs is achieving a continuous interface between host bone and graft to enhance biological processes and mechanical stability. In this study, we have developed a new bioengineering strategy to produce oriented biocompatible 3D PLGA/aCaP nanocomposites with enhanced osseointegration. Decellularized scaffolds -containing only extracellular matrix- or scaffolds seeded with adipose-derived mesenchymal stromal cells were tested in a mouse model for critical size bone defects. In parallel to micro-CT analysis, SAXS tensor tomography and 2D scanning SAXS were employed to determine the 3D arrangement and nanostructure within the critical-sized bone. Both newly developed scaffold types, seeded with cells or decellularized, showed high osseointegration, higher bone quality, increased alignment of collagen fibers and optimal alignment and size of hydroxyapatite minerals.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- SAXS tomography
- PLGA/aCaP
- Extracellular matrix
- Critical size bone defect
- Scaffold
- Mesenchymal stromal cells
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Casanova, Elisa ...
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Rodriguez Palomo ...
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Stähli, Lisa
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Arnke, Kevin
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Gröninger, Olivi ...
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Generali, Melani ...
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show more...
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Neldner, Yvonne
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Tiziani, Simon
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Dominguez, Ana P ...
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Guizar-Sicairos, ...
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Gao, Zirui
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Appel, Christian
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Nielsen, Leonard ...
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Georgiadis, Mari ...
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Weber, Franz E.
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Stark, Wendelin
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Pape, Hans Chris ...
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Cinelli, Paolo
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Liebi, Marianne, ...
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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and Bio Materials
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Material ...
- Articles in the publication
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Biomaterials
- By the university
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Chalmers University of Technology