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WFRF:(Haslam Danielle E.)
 

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  • Wang, FengleiHarvard School of Public Health, United States (author)

Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:be9ea10a-84b2-4e35-a05c-0ce10039f9e3
  • https://doi.org/10.1038/s41467-023-41515-zDOI
  • https://research.chalmers.se/publication/537608URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tessier, Anne JulieHarvard School of Public Health, United States (author)
  • Liang, LimingHarvard School of Public Health, United States,Harvard School of Public Health, United States (author)
  • Wittenbecher, Clemens,1981Harvard School of Public Health, United States,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)clemensw (author)
  • Haslam, Danielle E.Harvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Fernández-Duval, GonzaloUniversidad de Navarra,University of Navarra (author)
  • Heather Eliassen, A.Harvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Rexrode, KathrynBrigham and Women's Hospital,Harvard Medical School (author)
  • Tobias, Deirdre K.Harvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Li, JunHarvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Zeleznik, OanaBrigham and Women's Hospital (author)
  • Grodstein, FrancineRush University Medical Center (author)
  • Martínez-González, Miguel A.Harvard School of Public Health, United States,Universidad de Navarra,University of Navarra (author)
  • Salas-Salvadó, JordiUniversitat Rovira i Virgili,Rovira i Virgili University (author)
  • Clish, Clary B.Broad Institute (author)
  • Lee, Kyu HaHarvard School of Public Health, United States,Harvard School of Public Health, United States,Harvard School of Public Health, United States (author)
  • Sun, QiHarvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Stampfer, Meir J.Harvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Hu, Frank B.Harvard School of Public Health, United States,Brigham and Women's Hospital (author)
  • Guasch-Ferré, MartaHarvard School of Public Health, United States,Novo Nordisk Fonden,Novo Nordisk Foundation,Köpenhamns universitet,University of Copenhagen (author)
  • Harvard School of Public Health, United StatesChalmers tekniska högskola (creator_code:org_t)

Related titles

  • In:Nature Communications14:12041-17232041-1723

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