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EFFECT OF 2.45 GHZ ...
EFFECT OF 2.45 GHZ MICROWAVE-RADIATION ON PERMEABILITY OF UNILAMELLAR LIPOSOMES TO 5(6)-CARBOXYFLUORESCEIN - EVIDENCE OF NONTHERMAL LEAKAGE
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- Saalman, Elisabeth, 1955 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nordén, Bengt, 1945 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Arvidsson, Lars (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Hamnerius, Yngve, 1950 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Höjevik, Per (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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Connell, K. E. (författare)
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Kurucsev, T. (författare)
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(creator_code:org_t)
- Elsevier BV, 1991
- 1991
- Engelska.
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Ingår i: Biochimica Et Biophysica Acta. - : Elsevier BV. - 0006-3002 .- 0005-2736. ; 1064:1, s. 124-130
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- The influence of 2.45 GHz microwave radiation on the membrane permeability of unilamellar liposomes was studied using the marker 5(6)-carboxyfluorescein trapped in phosphatidylcholine liposomes. The release of the fluorescent marker was followed by spectrofluorimetry after an exposure of 10 minutes to either microwave radiation or to heat alone of the liposome solutions. A significant increase of the permeability of carboxyfluorescein through the membrane was observed for the microwave-exposed samples compared to those exposed to normal heating only. Exposure to 2.45 GHz microwave radiation of liposomes has been previously found to produce increased membrane permeability as compared with heating. However, in contrast to previous studies, the observations reported here were made above the phase transition temperature of the lipid membrane. The experimental setup included monitoring of the temperature during microwave exposure simultaneously at several points in the solution volume using a fiberoptic thermometer. Possible mechanisms to explain the observations are discussed.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- exposure
- 5(6)-carboxyfluorescein
- rabbit erythrocytes
- liposome
- phase-transition
- temperature
- vesicles
- membrane permeability
- efflux
- fluorescence
- membrane
- microwave radiation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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