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Biochemical princip...
Biochemical principles enabling metabolic cooperativity and phenotypic heterogeneity at the single cell level
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- Campbell, Kate, 1987 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Herrera-Dominguez, Lucia (author)
- The Francis Crick Institute
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- Correia-Melo, Clara (author)
- University Of Cambridge,The Francis Crick Institute
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- Zelezniak, Aleksej, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Science for Life Laboratory (SciLifeLab),The Francis Crick Institute
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- Ralser, M. (author)
- The Francis Crick Institute,University Of Cambridge
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Current Opinion in Systems Biology. - : Elsevier BV. - 2452-3100. ; 8, s. 97-108
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https://doi.org/10.1...
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Abstract
Subject headings
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- All biosynthetically active cells release metabolites, in part due to membrane leakage and cell lysis, but also in part due to overflow metabolism and ATP-dependent membrane export. At the same time, cells are adapted to sense and take up extracellular nutrients when available, to minimize the number of biochemical reactions that have to operate within a cell in parallel, and ultimately, to gain metabolic efficiency and biomass. Within colonies, biofilms or tissues, the co-occurrence of metabolite export and import enables the sharing of metabolites as well as metabolic specialization of single cells. In this review we discuss emerging biochemical concepts that give reasoning for why cells overproduce and release metabolites, and how these form the foundations for cooperative metabolite exchange activity between cells. We place particular emphasis on discussing the role of overflow metabolism in cells that exhibit either the Warburg or Crabtree effect. Furthermore, we discuss the profound physiological changes that cells undergo when their metabolism switches from metabolite synthesis to uptake, providing an explanation why metabolic specialization results in non-genotypic heterogeneity at the single cell level.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Crabtree effect
- Metabolite exchange
- Overflow metabolism
- Metabolite sensing
- Exometabolome
- Warburg effect
- Phenotypic heterogeneity
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- ref (subject category)
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