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Microbiota-derived ...
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Ahmed, HanyTurun Yliopisto,University of Turku
(författare)
Microbiota-derived metabolites as drivers of gut–brain communication
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-07-28
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Informa UK Limited,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:c618822e-79e9-4ab8-9734-39c132fcf3c6
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https://research.chalmers.se/publication/531488URI
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https://doi.org/10.1080/19490976.2022.2102878DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes transform and metabolize dietary- and host-derived molecules generating a diverse group of metabolites with local and systemic effects. The bi-directional communication between brain and the microbes residing in the gut, the so-called gut–brain axis, consists of a network of immunological, neuronal, and endocrine signaling pathways. Although the full variety of mechanisms of the gut–brain crosstalk is yet to be established, the existing data demonstrates that a single metabolite or its derivatives are likely among the key inductors within the gut–brain axis communication. However, more research is needed to understand the molecular mechanisms underlying how gut microbiota associated metabolites alter brain functions, and to examine if different interventional approaches targeting the gut microbiota could be used in prevention and treatment of neurological disorders, as reviewed herein. Abbreviations:4-EPS 4-ethylphenylsulfate; 5-AVA(B) 5-aminovaleric acid (betaine); Aβ Amyloid beta protein; AhR Aryl hydrocarbon receptor; ASD Autism spectrum disorder; BBB Blood–brain barrier; BDNF Brain-derived neurotrophic factor; CNS Central nervous system; GABA ɣ-aminobutyric acid; GF Germ-free; MIA Maternal immune activation; SCFA Short-chain fatty acid; 3M-4-TMAB 3-methyl-4-(trimethylammonio)butanoate; 4-TMAP 4-(trimethylammonio)pentanoate; TMA(O) Trimethylamine(-N-oxide); TUDCA Tauroursodeoxycholic acid; ZO Zonula occludens proteins.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Leyrolle, QuentinUniversite catholique de Louvain
(författare)
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Koistinen, Ville MikaelTurun Yliopisto,University of Turku,Itä-Suomen Yliopisto,University of Eastern Finland
(författare)
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Kärkkäinen, OlliItä-Suomen Yliopisto,University of Eastern Finland
(författare)
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Layé, SophieUniversité de Bordeaux,University of Bordeaux
(författare)
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Delzenne, NathalieUniversite catholique de Louvain
(författare)
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Hanhineva, Kati,1972Itä-Suomen Yliopisto,University of Eastern Finland,Chalmers tekniska högskola,Chalmers University of Technology,Turun Yliopisto,University of Turku(Swepub:cth)kati
(författare)
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Turun YliopistoUniversite catholique de Louvain
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Gut Microbes: Informa UK Limited14:11949-09841949-0976
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