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Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity—A Study on Rare BMI-Discordant Monozygotic Twin Pairs
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- Sahebekhtiari, Navid (author)
- Helsingin Yliopisto,University of Helsinki,Univ Helsinki, Diabet & Obes Res Program, Res Programs Unit, Obes Res Unit, FIN-00014 Helsinki, Finland. araswat, Mayank; Joenvaara, Sakari; Renkonen, Risto
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- Saraswat, Mayank (author)
- Helsingin Yliopisto,University of Helsinki,Helsinki University Central Hospital
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- Joenväärä, Sakari (author)
- Helsinki University Central Hospital,Helsingin Yliopisto,University of Helsinki
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- Jokinen, Riikka (author)
- Helsingin Yliopisto,University of Helsinki
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- Lovric, Alen (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Kaye, Sanna (author)
- Helsingin Yliopisto,University of Helsinki
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- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Rissanen, Aila (author)
- Helsingin Yliopisto,University of Helsinki
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- Kaprio, Jaakko (author)
- Helsingin Yliopisto,University of Helsinki
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- Renkonen, Risto (author)
- Helsingin Yliopisto,University of Helsinki,Helsinki University Central Hospital
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- Pietilainen, K. H. (author)
- Helsinki University Central Hospital,Helsingin Yliopisto,University of Helsinki
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Helsingin Yliopisto Univ Helsinki, Diabet & Obes Res Program, Res Programs Unit, Obes Res Unit, FIN-00014 Helsinki, Finland araswat, Mayank; Joenvaara, Sakari; Renkonen, Risto (creator_code:org_t)
- 2019-02-05
- 2019
- English.
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In: Proteomics - Clinical Applications. - : Wiley. - 1862-8354 .- 1862-8346. ; 13:4
- Related links:
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https://doi.org/10.1...
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Abstract
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- Purpose: The purpose of this study is to elucidate the effect of excess body weight and liver fat on the plasma proteome without interference from genetic variation. Experimental Design: The effect of excess body weight is assessed in young, healthy monozygotic twins from pairs discordant for body mass index (intrapair difference (Δ) in BMI > 3 kg m −2 , n = 26) with untargeted LC-MS proteomics quantification. The effect of liver fat is interrogated via subgroup analysis of the BMI-discordant twin cohort: liver fat discordant pairs (Δliver fat > 2%, n = 12) and liver fat concordant pairs (Δliver fat < 2%, n = 14), measured by magnetic resonance spectroscopy. Results: Seventy-five proteins are differentially expressed, with significant enrichment for complement and inflammatory response pathways in the heavier co-twins. The complement dysregulation is found in obesity in both the liver fat subgroups. The complement and inflammatory proteins are significantly associated with adiposity measures, insulin resistance and impaired lipids. Conclusions and Clinical Relevance: The early pathophysiological mechanisms in obesity are incompletely understood. It is shown that aberrant complement regulation in plasma is present in very early stages of clinically healthy obese persons, independently of liver fat and in the absence of genetic variation that typically confounds human studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- acquired obesity
- complement cascade
- monozygotic twins
- plasma proteomics
- label-free proteomics
Publication and Content Type
- art (subject category)
- ref (subject category)
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Sahebekhtiari, N ...
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Saraswat, Mayank
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Joenväärä, Sakar ...
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Jokinen, Riikka
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Lovric, Alen
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Kaye, Sanna
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Mardinoglu, Adil ...
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Rissanen, Aila
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Kaprio, Jaakko
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Renkonen, Risto
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Pietilainen, K. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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MEDICAL AND HEAL ...
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NATURAL SCIENCES
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- Articles in the publication
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Proteomics - Cli ...
- By the university
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Chalmers University of Technology
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Royal Institute of Technology