Sökning: WFRF:(Hjärtstam Johan 1962) >
The influence of th...
The influence of the molecular weight of the water-soluble polymer on phase-separated films for controlled release
-
- Andersson, Helene, 1983 (författare)
- RISE,SP Food and Bioscience,Chalmers University of Technology, Sweden
-
- Häbel, Henrike, 1987 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers University of Technology, Sweden
-
- Olsson, Anna, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden
-
visa fler...
-
- Sandhagen, Sofie (författare)
- RISE,SP Food and Bioscience,Chalmers University of Technology, Sweden
-
- von Corswant, Christian (författare)
- AstraZeneca AB,AstraZeneca, Sweden
-
- Hjärtstam, Johan, 1962 (författare)
- AstraZeneca AB,AstraZeneca, Sweden
-
- Persson, Michael, 1956 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden; AkzoNobel, Sweden
-
- Stading, Mats, 1962 (författare)
- RISE,Structure Design,Chalmers University of Technology, Sweden
-
- Larsson, Anette, 1966 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Sweden
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
-
Ingår i: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 511:1, s. 223-235
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://gup.ub.gu.se...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC) can be used for extended release coatings, where the water-soluble HPC may act as a pore former. The aim was to investigate the effect of the molecular weight of HPC on the microstructure and mass transport in phase-separated freestanding EC/HPC films with 30% w/w HPC. Four different HPC grades were used, with weight averaged molecular weights (Mw) of 30.0 (SSL), 55.0 (SL), 83.5 (L) and 365 (M) kg/mol. Results showed that the phase-separated structure changed from HPC-discontinuous to bicontinuous with increasing Mw of HPC. The film with the lowest Mw HPC (SSL) had unconnected oval-shaped HPC-rich domains, leaked almost no HPC and had the lowest water permeability. The remaining higher Mw films had connected complex-shaped pores, which resulted in higher permeabilities. The highest Mw film (M) had the smallest pores and very slow HPC leakage, which led to a slow increase in permeability. Films with grade L and SL released most of their HPC, yet the permeability of the L film was three times higher due to greater pore connectivity. It was concluded that the phase-separated microstructure, the level of pore percolation and the leakage rate of HPC will be affected by the choice of HPC Mw grade used in the film and this will in turn have strong impact on the film permeability.
Ämnesord
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Pellet formulation
- Controlled release
- Hydroxypropyl cellulose
- Phase separation
- Molecular weight
- Film coating
- Ethyl cellulose
- Controlled release; Ethyl cellulose; Film coating; Hydroxypropyl cellulose; Molecular weight; Pellet formulation; Phase separation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Andersson, Helen ...
-
Häbel, Henrike, ...
-
Olsson, Anna, 19 ...
-
Sandhagen, Sofie
-
von Corswant, Ch ...
-
Hjärtstam, Johan ...
-
visa fler...
-
Persson, Michael ...
-
Stading, Mats, 1 ...
-
Larsson, Anette, ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Fysik
-
och Annan fysik
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Biomaterialveten ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Chalmers tekniska högskola
-
Göteborgs universitet
-
RISE