Biofabrication of bacterial nanocellulose scaffolds with complex vascular structure

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: AMNE:(TEKNIK OCH TEKNOLOGIER Industriell bioteknik Bioteknisk apparatteknik) > Biofabrication of b...

Details
MARC

Sämfors, Sanna,1987Chalmers tekniska högskola,Chalmers University of Technology (author)

Biofabrication of bacterial nanocellulose scaffolds with complex vascular structure

Article/chapterEnglish2019

Publisher, publication year, extent ...

2019-07-25
IOP Publishing,2019
electronicrdacarrier

Numbers

LIBRIS-ID:oai:research.chalmers.se:d330c607-bbf3-4c6b-a0b5-62778a525e63
https://doi.org/10.1088/1758-5090/ab2b4fDOI
https://research.chalmers.se/publication/511902URI
https://research.chalmers.se/publication/511809URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Bacterial nanocellulose (BNC) has proven to be an effective hydrogel-like material for different tissue engineering applications due to its biocompatibility and good mechanical properties. However, as for all biomaterials, in vitro biosynthesis of large tissue constructs remains challenging due to insufficient oxygen and nutrient transport in engineered scaffold-cell matrices. In this study we designed, biofabricated and evaluated bacterial nanocellulose scaffolds with a complex vascular mimetic lumen structure. As a first step a method for creating straight channeled structures within a bacterial nanocellulose scaffold was developed and evaluated by culturing of Human Umbilical Vein Endothelial Cells (HUVECs). In a second step, more complex structures within the scaffolds were produced utilizing a 3D printer. A print mimicking a vascular tree acted as a sacrificial template to produce a network within the nanoporous bacterial nanocellulose scaffolds that could be lined with endothelial cells. In a last step, a method to produce large constructs with interconnected macro porosity and vascular like lumen structure was developed. In this process patient data from x-ray computed tomography scans was used to create a mold for casting a full-sized kidney construct. By showing that the 3D printing technology can be combined with BNC biosynthesis we hope to widen the opportunities of 3D printing, while also enabling the production of BNC scaffolds constructs with tailored vascular architectures and properties.

Subject headings and genre

TEKNIK OCH TEKNOLOGIER Industriell bioteknik Biomaterial hsv//swe
ENGINEERING AND TECHNOLOGY Industrial Biotechnology Bio Materials hsv//eng
TEKNIK OCH TEKNOLOGIER Industriell bioteknik Bioteknisk apparatteknik hsv//swe
ENGINEERING AND TECHNOLOGY Industrial Biotechnology Bioengineering Equipment hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomaterialvetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomaterials Science hsv//eng
HUVECs
bacterial nanocellulose
3D printing
tissue engineering
vascular mimetic

Added entries (persons, corporate bodies, meetings, titles ...)

Karlsson, Kristina,1988Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)krikarl (author)
Sundberg, Johan,1982Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)sundberj (author)
Markstedt, Kajsa,1989Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)kajsam (author)
Gatenholm, Paul,1956Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatenh (author)
Chalmers tekniska högskola (creator_code:org_t)

Related titles

In:Biofabrication: IOP Publishing11:41758-50821758-5090

Internet link

Find in a library

Biofabrication (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Sämfors, Sanna, ...; Karlsson, Kristi ...; Sundberg, Johan, ...; Markstedt, Kajsa ...; Gatenholm, Paul, ...

About the subject

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Industrial Biote ...; and Bio Materials

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Industrial Biote ...; and Bioengineering E ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomaterials Sci ...

Articles in the publication: Biofabrication

By the university: Chalmers University of Technology

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se