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  • Brodkorb, A.Teagasc - Irish Agriculture and Food Development Authority (author)

INFOGEST static in vitro simulation of gastrointestinal food digestion

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-03-18
  • Springer Science and Business Media LLC,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:db5a450f-9f41-448a-8bcd-dbbaea6fe5e7
  • https://research.chalmers.se/publication/509600URI
  • https://doi.org/10.1038/s41596-018-0119-1DOI
  • https://research.chalmers.se/publication/509233URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus developed by the COST INFOGEST network. The method is designed to be used with standard laboratory equipment and requires limited experience to encourage a wide range of researchers to adopt it. It is a static digestion method that uses constant ratios of meal to digestive fluids and a constant pH for each step of digestion. This makes the method simple to use but not suitable for simulating digestion kinetics. Using this method, food samples are subjected to sequential oral, gastric and intestinal digestion while parameters such as electrolytes, enzymes, bile, dilution, pH and time of digestion are based on available physiological data. This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method, such as the inclusion of the oral phase and the use of gastric lipase. The method can be used to assess the endpoints resulting from digestion of foods by analyzing the digestion products (e.g., peptides/amino acids, fatty acids, simple sugars) and evaluating the release of micronutrients from the food matrix. The whole protocol can be completed in ~7 d, including ~5 d required for the determination of enzyme activities.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Egger, L.Forschungsanstalt Agroscope Changins-Wadenswil (author)
  • Alminger, Marie,1957Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)mariealm (author)
  • Alvito, P.Universidade de Aveiro,University of Aveiro (author)
  • Assunção, RicardoUniversidade de Aveiro,University of Aveiro (author)
  • Ballance, S.Norwegian Institute of Food, Fisheries and Aquaculture Research (Nofima) (author)
  • Bohn, T.Luxembourg Institute of Health (author)
  • Bourlieu-Lacanal, Claire (author)
  • Boutrou, R. (author)
  • Carriere, F.Centre national de la recherche scientifique (CNRS) (author)
  • Clemente, Alfonso (author)
  • Corredig, M.Århus Universitet,Aarhus University (author)
  • Dupont, D. (author)
  • Dufour, C. (author)
  • Edwards, Cathrina (author)
  • Golding, M.Massey University (author)
  • Karakaya, S.Ege Universitesi,Ege University (author)
  • Kirkhus, B.Norwegian Institute of Food, Fisheries and Aquaculture Research (Nofima) (author)
  • Le Feunteun, S. (author)
  • Lesmes, U.Technion – Israel Institute of Technology (author)
  • Macierzanka, A.Politechnika Gdańska,Gdansk University of Technology (author)
  • Mackie, A.University of Leeds (author)
  • Martins, CarlaUniversidade de Aveiro,University of Aveiro (author)
  • Marze, S. (author)
  • McClements, D. J.University of Massachusetts (author)
  • Menard, O. (author)
  • Minekus, M. (author)
  • Portmann, RetoForschungsanstalt Agroscope Changins-Wadenswil (author)
  • Santos, C. N.Nova University of Lisbon, Portugal,Instituto de Biologia Experimental e Tecnologica (author)
  • Souchon, IsabelleUniversité Paris-Saclay,University Paris-Saclay (author)
  • Singh, R. PaulUniversity of California (author)
  • Vegarud, G. E.Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU) (author)
  • Wickham, M. S. J. (author)
  • Weitschies, W.Universität Greifswald,University of Greifswald (author)
  • Recio, I.Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL) (author)
  • Teagasc - Irish Agriculture and Food Development AuthorityForschungsanstalt Agroscope Changins-Wadenswil (creator_code:org_t)

Related titles

  • In:Nature Protocols: Springer Science and Business Media LLC14:4, s. 991-10141754-21891750-2799

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