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Genetically control...
Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation
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- Stenberg, Simon (author)
- Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU),Göteborgs universitet,University of Gothenburg
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- Li, Jing (author)
- Sun Yat-Sen University,Université Côte d'Azur,University of Côte d'Azur
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- Gjuvsland, Arne B. (author)
- Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU)
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- Persson, Karl, 1988 (author)
- Göteborgs universitet,University of Gothenburg
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- Demitz-Helin, Erik (author)
- Göteborgs universitet,University of Gothenburg
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- Gonzalez-Pena, Carles (author)
- Göteborgs universitet,University of Gothenburg
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- Yue, Jia Xing (author)
- Sun Yat-Sen University
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- Gilchrist, Ciaran (author)
- Göteborgs universitet,University of Gothenburg
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- Ärengård, Timmy (author)
- Göteborgs universitet,University of Gothenburg
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- GHIACI, PAYAM, 1982 (author)
- Göteborgs universitet,University of Gothenburg
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- Larsson-Berglund, Lisa (author)
- Göteborgs universitet,University of Gothenburg
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- Zackrisson, Martin (author)
- Göteborgs universitet,University of Gothenburg
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- Smits, Silvana (author)
- Göteborgs universitet,University of Gothenburg
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- Hallin, Johan (author)
- Göteborgs universitet,University of Gothenburg
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- Höög, Johanna L. (author)
- Göteborgs universitet,University of Gothenburg
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- Molin, Mikael, 1973 (author)
- Göteborgs universitet,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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Liti, Gianni (author)
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- Omholt, Stig (author)
- Norges teknisk-naturvitenskapelige universitet (NTNU),Norwegian University of Science and Technology (NTNU)
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- Warringer, Jonas, 1973 (author)
- Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- 2022-07-08
- 2022
- English.
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In: eLife. - : eLife Sciences Publications, Ltd. - 2050-084X. ; 11
- Related links:
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.7...
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Abstract
Subject headings
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- Deletion of mitochondrial DNA in eukaryotes is currently attributed to rare accidental events associated with mitochondrial replication or repair of double-strand breaks. We report the discovery that yeast cells arrest harmful intramitochondrial superoxide production by shutting down respiration through genetically controlled deletion of mitochondrial oxidative phosphorylation genes. We show that this process critically involves the antioxidant enzyme superoxide dismutase 2 and two-way mitochondrial-nuclear communication through Rtg2 and Rtg3. While mitochondrial DNA homeostasis is rapidly restored after cessation of a short-term superoxide stress, long-term stress causes maladaptive persistence of the deletion process, leading to complete annihilation of the cellular pool of intact mitochondrial genomes and irrevocable loss of respiratory ability. This shows that oxidative stress-induced mitochondrial impairment may be under strict regulatory control. If the results extend to human cells, the results may prove to be of etiological as well as therapeutic importance with regard to age-related mitochondrial impairment and disease.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- mitochondrial impairment
- oxidative stress
- mtDNA
- genome editing
Publication and Content Type
- art (subject category)
- ref (subject category)
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eLife
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To the university's database
- By the author/editor
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Stenberg, Simon
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Li, Jing
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Gjuvsland, Arne ...
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Persson, Karl, 1 ...
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Demitz-Helin, Er ...
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Gonzalez-Pena, C ...
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show more...
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Yue, Jia Xing
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Gilchrist, Ciara ...
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Ärengård, Timmy
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GHIACI, PAYAM, 1 ...
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Larsson-Berglund ...
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Zackrisson, Mart ...
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Smits, Silvana
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Hallin, Johan
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Höög, Johanna L.
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Molin, Mikael, 1 ...
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Liti, Gianni
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Omholt, Stig
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Warringer, Jonas ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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eLife
- By the university
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Chalmers University of Technology