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  • Agah, ShahramUniversity of Adelaide,Iran University of Medical Sciences (author)

Systematic review with meta-analysis: Effects of probiotic supplementation on symptoms in functional dyspepsia

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:e29013fe-32e8-4780-947b-f3d30ee4471b
  • https://research.chalmers.se/publication/517121URI
  • https://doi.org/10.1016/j.jff.2020.103902DOI
  • https://research.chalmers.se/publication/517411URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The pathophysiology of functional dyspepsia (FD) remains poorly understood, but alterations of the small intestinal microbiome have been observed. The place of probiotics in treatment is uncertain. We performed a systematic review and meta-analysis of the currently available randomized, controlled trials (RCTs) to evaluate the potential beneficial effects and risks of probiotics in FD. Pubmed, EMBASE, Scopus, Web of Science and the Cochrane Controlled Trials Register were searched (up to May 2019) for RCTs evaluating the effects of probiotic supplementation compared to placebo in adults with FD. Two reviewers independently assessed eligibility, trial quality and extracted information from identified articles. To compare the effects of probiotics with placebo, risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random effects models. Six trials, including 422 participants were included but only three RCTs could be included in the meta-analysis. Lactobacillus strains showed potential positive effects in terms of improving upper gastrointestinal (GI) symptoms in patients with FD. Probiotic supplementation tended to improve global dyspepsia score (n = 3 RCTs, risk ratio [RR]: 1.35, 95% CI 0.99 to 1.84; P = 0.061) and bacterial composition in the GI tract. Probiotics were well tolerated without any serious adverse events. While the available data suggest that supplementation with probiotics may improve GI symptoms in patients with FD, the evidence is insufficient to draw clear conclusions regarding efficacy. Thus, high-quality RCTs are needed to establish the beneficial effects of probiotic supplementation on FD outcomes.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Akbari, AbolfazlIran University of Medical Sciences (author)
  • Heshmati, JavadKermanshah University of Medical Sciences (author)
  • Sepidarkish, MahdiBabol University of Medical Sciences (author)
  • Morvaridzadeh, MojganKermanshah University of Medical Sciences (author)
  • Adibi, PaymanIsfahan University of Medical Sciences (author)
  • Mazidi, Mohsen,1989Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)mazidi (author)
  • Farsi, FarnazIran University of Medical Sciences (author)
  • Ofori-Asenso, RichardMonash University (author)
  • Talley, Nicholas J.University of Newcastle (author)
  • Feinle-Bisset, ChristineUniversity of Adelaide (author)
  • University of AdelaideIran University of Medical Sciences (creator_code:org_t)

Related titles

  • In:Journal of Functional Foods: Elsevier BV681756-4646

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