Ultrasound-assisted synthesis of organotin compounds and their application as luminescent dye in silk fibroin scaffolds

In this work, we report the green synthesis of four luminescent organotin compounds 1–4 derived from amino acid Schiff bases (1: Naph-Trp-SnPh2, 2: Naph-Tyr-SnBu2, 3: Naph-Tyr-SnPh2, 4: Naph-Phe-SnPh2), obtained by ultrasound-assisted synthesis in short time (~20 min) and good yields (>95%). The molecular structure proposed in solution (1H and 119Sn NMR) was confirmed by X-ray diffraction study for compound 1 where the tin atom resides in trigonal bipyramid geometry. Luminescent silk fibroin scaffolds (SF 1–4) were elaborated with organotin compounds by freeze-drying technique. Photophysical properties of organotin compounds and scaffolds were obtained in solid state, observing bathochromic behaviors in tyrosine derived compounds, suggesting that the tyrosine produce supramolecular interactions across the –OH group that change the fluorescent properties. Scaffolds 1–4 were characterized by FTIR, XDR, TG/DTG, and SEM analysis. In addition, cytotoxic analysis of SF 1 presents high cellular viability, which could be applied as a scaffold in tissue engineering.

Jiménez-Pérez, Víctor M.Universidad Autonoma de Nuevo Leon (UANL) (författare)
Molina-Paredes, Areli A.Universidad Autonoma de Nuevo Leon (UANL) (författare)
Ochoa, María E.Centro de Investigacion y de Estudios Avanzados (CINVESTAV),Centro de Investigacion y de Estudios Avanzados Centro de Investigacion y de Estudios Avanzados (CINVESTAV) (författare)
Sábio, Rafael M.Universidade de Araraquara,University of Araraquara (författare)
Amaral, André C.Universidade de Araraquara,University of Araraquara (författare)
Rosa Da Silva, Robson,1988Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)rosa (författare)
Ribeiro, Sidney J.L.Universidade Estadual Paulista (UNESP),São Paulo State University (UNESP) (författare)
da S. Barud, HernaneUniversidade de Araraquara,University of Araraquara (författare)
Muñoz-Flores, Bianca M.Universidad Autonoma de Nuevo Leon (UANL) (författare)
Universidad Autonoma de Nuevo Leon (UANL)Centro de Investigacion y de Estudios Avanzados (CINVESTAV) (creator_code:org_t)

Av författaren/redakt...: Lara-Cerón, Jesú ...; Jiménez-Pérez, V ...; Molina-Paredes, ...; Ochoa, María E.; Sábio, Rafael M.; Amaral, André C.; visa fler...; Rosa Da Silva, R ...; Ribeiro, Sidney ...; da S. Barud, Her ...; Muñoz-Flores, Bi ...; visa färre...

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