Sökning: WFRF:(Kyro C.) >
Effects of whole-gr...
Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: A randomized crossover trial
-
- Eriksen, Anne Kirstine (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Danish Cancer Research Society Center, Denmark,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Danish Cancer Society Research Center,Swedish Univ Agr Sci, Dept Mol Sci, Uppsala, Sweden;Danish Canc Soc Res Ctr, Unit Diet Genes & Environm, Copenhagen, Denmark
-
- Brunius, Carl, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, Gothenburg, Sweden
-
- Mazidi, Mohsen, 1989 (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
visa fler...
-
- Hellström, Per M. (författare)
- Uppsala universitet,Uppsala University
-
- Risérus, Ulf, 1967- (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
-
- Iversen, Kia Noehr, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, Gothenburg, Sweden
-
- Fristedt, Rikard (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, Gothenburg, Sweden
-
- Sun, Li (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Swedish Univ Agr Sci, Dept Mol Sci, Uppsala, Sweden
-
- Huang, Yi (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens utfodring och vård (HUV),Department of Animal Nutrition and Management,Guangxi University,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Swedish Univ Agr Sci, Dept Anim Nutr & Management, Uppsala, Sweden;Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China
-
- Nørskov, N. (författare)
- Århus Universitet,Aarhus University,Aarhus Univ, Dept Anim Sci, Tjele, Denmark
-
- Knudsen, Knud Erik B. (författare)
- Århus Universitet,Aarhus University,Aarhus Univ, Dept Anim Sci, Tjele, Denmark
-
- Kyro, C. (författare)
- Danish Cancer Research Society Center, Denmark,Danish Canc Soc Res Ctr, Unit Diet Genes & Environm, Copenhagen, Denmark
-
- Olsen, A. (författare)
- Danish Cancer Research Society Center, Denmark,Danish Canc Soc Res Ctr, Unit Diet Genes & Environm, Copenhagen, Denmark
-
- Tjønneland, Anne (författare)
- Danish Cancer Research Society Center, Denmark,Danish Canc Soc Res Ctr, Unit Diet Genes & Environm, Copenhagen, Denmark
-
- Dicksved, Johan (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens utfodring och vård (HUV),Department of Animal Nutrition and Management,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Swedish Univ Agr Sci, Dept Anim Nutr & Management, Uppsala, Sweden
-
- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, Gothenburg, Sweden
-
visa färre...
-
(creator_code:org_t)
-
- Elsevier BV, 2020
- 2020
- Engelska.
-
Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 111:4, s. 864-876
- Relaterad länk:
-
https://research.cha... (primary) (free)
-
visa fler...
-
https://academic.oup...
-
https://research.cha...
-
https://research.cha...
-
https://doi.org/10.1...
-
https://res.slu.se/i...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- A whole-grain (WG)-rich diet has shown to have potential for both prevention and treatment of the metabolic syndrome (MetS), which is a cluster of risk factors that increase the risk of type 2 diabetes and cardiovascular disease. Different WGs may have different health effects. WG rye, in particular, may improve glucose homeostasis and blood lipids, possibly mediated through fermentable dietary fiber and lignans. Recent studies have also suggested a crucial role of the gut microbiota in response to WG. Objectives: The aim was to investigate WG rye, alone and with lignan supplements [secoisolariciresinol diglucoside (SDG)], and WG wheat diets on glucose tolerance [oral-glucose-tolerance test (OGTT)], other cardiometabolic outcomes, enterolignans, and microbiota composition. Moreover, we exploratively evaluated the role of gut microbiota enterotypes in response to intervention diets. Methods: Forty men with MetS risk profile were randomly assigned to WG diets in an 8-wk crossover study. The rye diet was supplemented with 280 mg SDG at weeks 4-8. Effects of treatment were evaluated by mixed-effects modeling, and effects on microbiota composition and the role of gut microbiota as a predictor of response to treatment were analyzed by random forest plots. Results: The WG rye diet (± SDG supplements) did not affect the OGTT compared with WG wheat. Total and LDL cholesterol were lowered (-0.06 and -0.09 mmol/L, respectively; P < 0.05) after WG rye compared with WG wheat after 4 wk but not after 8 wk. WG rye resulted in higher abundance of Bifidobacterium [fold-change (FC) = 2.58, P < 0.001] compared with baseline and lower abundance of Clostridium genus compared with WG wheat (FC = 0.54, P = 0.02). The explorative analyses suggest that baseline enterotype is associated with total and LDL-cholesterol response to diet. Conclusions: WG rye, alone or with SDG supplementation, compared with WG wheat did not affect glucose metabolism but caused transient LDL-cholesterol reduction. The effect of WG diets appeared to differ according to enterotype. This trial was registered at www.clinicaltrials.gov as NCT02987595.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- enterotype
- wheat
- lipid profile
- cardiometabolic
- rye
- lignan
- whole grain
- glucose-tolerance test
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Eriksen, Anne Ki ...
-
Brunius, Carl, 1 ...
-
Mazidi, Mohsen, ...
-
Hellström, Per M ...
-
Risérus, Ulf, 19 ...
-
Iversen, Kia Noe ...
-
visa fler...
-
Fristedt, Rikard
-
Sun, Li
-
Huang, Yi
-
Nørskov, N.
-
Knudsen, Knud Er ...
-
Kyro, C.
-
Olsen, A.
-
Tjønneland, Anne
-
Dicksved, Johan
-
Landberg, Rikard ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Annan klinisk me ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Chalmers tekniska högskola
-
Sveriges Lantbruksuniversitet
-
Uppsala universitet