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Spatial Lipidomics ...
Spatial Lipidomics Reveals Region and Long Chain Base Specific Accumulations of Monosialogangliosides in Amyloid Plaques in Familial Alzheimer's Disease Mice (5xFAD) Brain
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- Kaya, Ibrahim (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Department of Chemistry and Molecular Biology,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, S-43180 Molndal, Sweden;Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden;Univ Gothenburg, Gothenburg Imaging Mass Spectrometry Go IMS Platf, Gothenburg, Sweden;Chalmers Univ Technol, Gothenburg, Sweden
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- Jennische, Eva, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Univ Gothenburg, Inst Biomed, S-40530 Gothenburg, Sweden
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- Dunevall, Johan, 1984 (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden
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- Lange, Stefan, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Univ Gothenburg, Inst Biomed, S-40530 Gothenburg, Sweden
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- Ewing, Andrew G, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden;Univ Gothenburg, Gothenburg Imaging Mass Spectrometry Go IMS Platf, Gothenburg, Sweden;Chalmers Univ Technol, Gothenburg, Sweden
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- Malmberg, Per, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden
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- Baykal, Ahmet Tarik (författare)
- Acibadem Universitesi,Acibadem University,Acibadem Mehmet Ali Aydinlar Univ, Dept Med Biochem, Fac Med, TR-34752 Istanbul, Turkey
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- Fletcher, John S. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden;Univ Gothenburg, Gothenburg Imaging Mass Spectrometry Go IMS Platf, Gothenburg, Sweden;Chalmers Univ Technol, Gothenburg, Sweden
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(creator_code:org_t)
- 2019-11-27
- 2020
- Engelska.
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Ingår i: ACS Chemical Neuroscience. - : American Chemical Society (ACS). - 1948-7193. ; 11:1, s. 14-24
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ganglioside metabolism is significantly altered in Alzheimer's disease (AD), which is a progressive neuro-degenerative disease prominently characterized by one of its pathological hallmarks, amyloid deposits or "senile plaques". While the plaques mainly consist of aggregated variants of amyloid-beta protein (A beta), recent studies have revealed a number of lipid species including gangliosides in amyloid plaques along with A beta peptides. It has been widely suggested that long chain (sphingosine) base (LCBs), C18:1-LCB and C20:1-LCB, containing gangliosides might play different roles in neuronal function in vivo. In order to elucidate region-specific aspects of amyloid-plaque associated C18:1-LCB and C20:1-LCB ganglioside accumulations, high spatial resolution (10 mu m per pixel) matrix assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) of gangliosides in amyloid plaques was performed in hippocampal and adjacent cortical regions of 12 month old 5xFAD mouse coronal brain sections from two different stereotaxic coordinates (bregma points, -2.2 and -2.7 mm). MALDI-IMS uncovered brain-region (2 and 3D) and/or LCB specific accumulations of monosialogangliosides (GMs): GM1, GM2, and GM3 in the hippocampal and cortical amyloid plaques. The results reveal monosialogangliosides to be an important component of amyloid plaques and the accumulation of different gangliosides is region and LCB specific in 12 month old 5xFAD mouse brain. This is discussed in relation to amyloid-associated AD pathogenesis such as lipid related immune changes in amyloid plaques, AD specific ganglioside metabolism, and, notably, AD-associated impaired neurogenesis in the subgranular zone.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- amyloid plaques
- monosialogangliosides
- MALDI imaging mass spectrometry
- sialic acid
- gangliosides
- Alzheimer's disease
- neurogenesis
- dentate gyrus
- 5xFAD
- 5xFAD Alzheimer’s dis
- ease
- MALDI imaging mass spectrometry
- amyloid plaques
- dentate gyrus
- gangliosides
- monosialogangliosides
- neurogenesis
- sialic acid.
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Kaya, Ibrahim
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Jennische, Eva, ...
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Dunevall, Johan, ...
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Lange, Stefan, 1 ...
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Ewing, Andrew G, ...
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Malmberg, Per, 1 ...
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Baykal, Ahmet Ta ...
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Fletcher, John S ...
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