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  • Apelgren, PeterGöteborgs universitet,University of Gothenburg (author)

Skin Grafting on 3D Bioprinted Cartilage Constructs In Vivo

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018
  • electronicrdacarrier

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  • LIBRIS-ID:oai:research.chalmers.se:ee536349-211d-4ca0-85ec-0dbc689e4d9f
  • https://doi.org/10.1097/GOX.0000000000001930DOI
  • https://research.chalmers.se/publication/506219URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Three-dimensional (3D) bioprinting of cartilage is a promising new technique. To produce, for example, an auricle with good shape, the printed cartilage needs to be covered with skin that can grow on the surface of the construct. Our primary question was to analyze if an integrated 3D bioprinted cartilage structure is a tissue that can serve as a bed for a full-thickness skin graft. Methods: 3D bioprinted constructs (10x10x1.2mm) were printed using nanofibrillated cellulose/alginate bioink mixed with mesenchymal stem cells and adult chondrocytes and implanted subcutaneously in 21 nude mice. Results: After 45 days, a full-thickness skin allograft was transplanted onto the constructs and the grafted construct again enclosed subcutaneously. Group 1 was sacrificed on day 60, whereas group 2, instead, had their skin-bearing construct uncovered on day 60 and were sacrificed on day 75 and the explants were analyzed morphologically. The skin transplants integrated well with the 3D bioprinted constructs. A tight connection between the fibrous, vascularized capsule surrounding the 3D bioprinted constructs and the skin graft were observed. The skin grafts survived the uncovering and exposure to the environment. Conclusions: A 3D bioprinted cartilage that has been allowed to integrate in vivo is a sufficient base for a full-thickness skin graft. This finding accentuates the clinical potential of 3D bioprinting for reconstructive purposes.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Amoroso, MatteoGöteborgs universitet,University of Gothenburg (author)
  • Saeljoe, KarinGöteborgs universitet,University of Gothenburg (author)
  • Lindahl, AndersSahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (author)
  • Brantsing, CamillaSahlgrenska universitetssjukhuset,Sahlgrenska University Hospital (author)
  • Strid Orrhult, Linnea,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)lstrid (author)
  • Gatenholm, Paul,1956Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gatenh (author)
  • Kolby, LarsGöteborgs universitet,University of Gothenburg (author)
  • Göteborgs universitetSahlgrenska universitetssjukhuset (creator_code:org_t)

Related titles

  • In:Plastic and Reconstructive Surgery - Global Open6:92169-7574

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