Site-specific adhesion of Staphylococcus epidermidis (RP12) in Ti-Al-V metal systems

Staphylococcus epidermidis (RP12) adhesion patterns were studied on the following titanium (Ti)-aluminium (Al)-vanadium (V) metal systems: (i) microfabricated samples consisting of Ti, Al and V islands deposited onto Ti or V substrata, (ii) pure Ti, Al and V metals, and (iii) medical grade Ti6Al4-V alloy. All of these surfaces were covered with their respective oxides formed upon exposure of the metals to air. Quantitative analysis of the number of cells bound per unit area indicates that S. epidermidis (RP12) exhibits greatest adhesion to pure V surfaces. When exposed to surfaces having controlled spatial variations in chemical composition on the 10 mu m scale (microfabricated samples), the bacteria preferentially populate V islands versus Ti or Al substrata. In the case of the biphasic Ti6Al4V alloy, the bacteria tend to adhere to V-rich, mixed phase regions and phase boundaries. These findings demonstrate that enhanced and preferential adhesion of S. epidermidis (RP12) occurs on V surfaces in TI-Al-V metal systems and suggest that bacterial interactions are influenced by surface oxide composition.

Gold, Julie,1963Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)f7xjg (författare)
Gristina, A. G. (författare)
Kasemo, Bengt Herbert,1942Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)kasemo (författare)
Lausmaa, Jukka,1959Chalmers tekniska högskola,Chalmers University of Technology (författare)
Harrer, C. (författare)
Myrvik, Q. N. (författare)
Chalmers tekniska högskola (creator_code:org_t)

Av författaren/redakt...: Gabriel, B. L.; Gold, Julie, 196 ...; Gristina, A. G.; Kasemo, Bengt He ...; Lausmaa, Jukka, ...; Harrer, C.; visa fler...; Myrvik, Q. N.; visa färre...

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