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- Andersson, J.Akademiska Sjukhuset (författare)
The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
- 2009-02-21
- Wiley,2009
Nummerbeteckningar
- LIBRIS-ID:oai:research.chalmers.se:f143429f-dc7c-4405-b136-edbdaae237d1
- https://doi.org/10.1007/s11745-009-3281-yDOI
- https://research.chalmers.se/publication/114165URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Carotid plaques can be characterised by ultrasound by size and echogenicity. Both size and echogenicity are predictors of cardiovascular events. The aim of this study was to examine whether traditional risk factors and markers of inflammation and oxidation were associated with plaque size and echogenicity. Computerised analysis of carotid plaque size and echogenicity (grey scale median, GSM) were performed by ultrasound in a population-based health survey in 1,016 subjects aged 70 years (PIVUS study). Information on cardiovascular risk factors was collected, together with markers of inflammation and oxidation. Increased Framingham risk score, systolic blood pressure, higher BMI and decreased HDL, lower glutathione levels were related to echolucent plaques. Previous or present smoking was common with significantly more pack-years related to the echorich plaques. Plaque size was associated with increased Framingham risk score, systolic blood pressure, blood glucose levels, smoking, ApoB/A1 ratio, OxLDL, TNF alpha, HOMA insulin resistance, leucocyte count, decreased BCD-LDL and low levels of l-selectin. Low HDL, increased BMI and decreased glutathione levels were associated with the echolucency of carotid plaques, implying metabolic factors to play a role for plaque composition. Markers of inflammation were related to plaque size alone, implying inflammation to be predominantly associated with the amount of atherosclerosis. These results suggest that plaque size and echogenicity are influenced by different risk factors.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Carotid artery
- Atherosclerosis
- men
- coronary-heart-disease
- density-lipoprotein cholesterol
- atherosclerosis
- independent predictor
- prevalence
- tromso
- seniors pivus
- Oxidation
- Plaque
- general-population
- Ultrasound
- Risk factor
- count
- leukocyte
- uppsala
- Lipids
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Sundstrom, J.Akademiska Sjukhuset (författare)
- Kurland, L.Akademiska Sjukhuset (författare)
- Gustavsson, Tomas,1954Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gustav (författare)
- Hulthe, Johannes,1970AstraZeneca AB (författare)
- Elmgren, A.AstraZeneca AB (författare)
- Zilmer, K.Tartu Ülikool,University of Tartu (författare)
- Zilmer, M.Tartu Ülikool,University of Tartu (författare)
- Lind, L.Akademiska Sjukhuset (författare)
- Akademiska SjukhusetChalmers tekniska högskola (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Lipids: Wiley44:5, s. 397-4030024-42011558-9307
Internetlänk
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